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EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent

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Figure 1 synthesis and characterization of Pla-10r5-Pla copolymer.Notes: (A) synthesis scheme of the Pla–10r5–Pla block copolymer; (B) FTIr spectrum (KBr) of reverse pluronic®10r5 (a) and copolymer s1, Pla–10r5–Pla, Mn=4.6×103 (b); (C) gPc curves of the prepared Pla–10r5–Pla block copolymers, s1, Mn=4.6×103, s2, Mn=19.8×103.Abbreviations: Pla, polylactic acid; 10r5, reverse Pluronic®10r5; FTIr, Fourier transform infrared spectroscopy; gPc, gel permeation chromatography; Mn, number-average molecular weight; sn(Oct)2, stannous octoate.
Table 1 The Pla–10r5–Pla copolymers synthesized in this work
Table 2 The Pla–10r5–Pla copolymer nanoparticles prepared in this work
Figure 4 In vitro cytotoxicity and drug release study.Notes: cell viability test of heK293 cells (A) and 3T3 cells (B) after incubation with egF-cur-NP/h extracts of different concentrations (100%, 50%, 25%, 0% as the negative control, and 0.1% phenol as t
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