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MK-2206 co-treatment with 5-fluorouracil or doxorubicin enhances chemosensitivity and apoptosis in gastric cancer by attenuation of Akt phosphorylation

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Academic year: 2020

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Figure

Table 1 ic50 values of MK-2206 in sgc-7901 and MKn45 cells
Table 2 The synergistic effect of MK-2206 combined with doxorubicin or 5-FU in sgc-7901 and MKn45 cellsa
Figure 4 Effect of Akt inhibitor MK-2206 on Akt phosphorylation (p-Akt) in gastric cancer cells.Notes: (A) Dose-dependent response
Figure 5 effect of MK-2206 on induction of caspase cascade by doxorubicin or 5-FU.Notes: SGC-7901 cells were treated with (A) doxorubicin (0, 0.1, 0.2, 0.8 μM) or (B) 5-FU (0, 12, 24, 96 μg/mL) in the presence of MK-2206 (1 μM) or DMsO vehicle for 24 hours

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