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Stability of a Long Noncoding Viral RNA Depends on a 9-nt Core Element at the RNA 5' End to Interact with Viral ORF57 and Cellular PABPC1

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Figure

Fig. 1. PAN expression depends on viral ORF57. (A) ORF57 binds PAN RNA during lytic KSHV infection
Fig. 2. ORF57-mediated enhancement of PAN expression depends on a 5' PAN element. Shown in (A) are schematic diagrams of wt PAN and its deletion mutants
Fig. 3. Stability of PAN depends on MRE and ORF57. (A) Calculation of half life of wt PAN and mt PANΔ1 lacking the 5' MRE in the presence or absence of ORF57
Fig. 4. Motif II (MRE-II) of the PAN 5' MRE is necessary for ORF57 enhancement of PAN expression
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