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Direct Access to New Gem-Difluorinated Pyrido [1,2-A] Pyrimidine-2-One Systems

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Figure

Figure 1: Examples of bioactive pyrido[1,2-a]pyrimidin-2-ones and pyrido[1,2-a]pyrimidin-4-ones.
Table 1: Cycloaddition reaction between gem-difluorinated alkynes and 2-aminopyridines.
Table 2: Suzuki coupling reaction of 4-[(3-bromophenyl) difluoromethyl]-2H-pyrido[1,2-a]pyrimidin-2-one 3b.

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