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Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo

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Academic year: 2020

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Figure 1 Molecular model of tumor targeting drug carrier ATF–HSA, the binding site of DOX in HSA, and the loading of the DOX into this carrier by the DIP method.Notes: DOX tends to form aggregates, hindering its embedding inside the carrier
Figure 2 cellular uptakes of aTF–hsa:DOX (5 μM), HSA:DOX (5 μM), and DOX (5 μM) in h1299 cells and helF cells after incubation for different time periods.Notes: The uptake amount of free DOX in both cell lines was much more than that of aTF–hsa:DOX
Figure 3 Cellular localization of ATF–HSA:DOX and DOX.Notes: aTF–hsa:DOX (5 μM) mainly distributes in cytoplasm, whereas DOX (5 μM) mainly localizes in nucleus in both H1299 cells and HELF cells after a 2 hours or  12 hours incubation period
Figure 4 ecIs results for h1299 cells incubated with or without 50 μM aTF–hsa:DOX or DOX.Notes: Time course of the impedance values measured by ECIS at 16,000 Hz using h1299 cells treated with aTF–hsa:DOX (50 μM) or DOX (50 μM) for 12 hours, and the photog
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