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The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signalling

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Figure

Figure 1: MIB2 interacts with CYLD. (A) MIB2 interacts with CYLD in GST pull down assays
Table 1: Notch target genes are upregulated in CYLD defective tumours. Gene expression data from 32 cylindroma tumours and 10 control perilesional skin samples were pooled into tumour and control groups
Figure 2: Characterisation of the ubiquitylation status and protein levels of CYLD and MIB2
Figure 3: CYLD ablation results in increased Notch signalling. (A) HEK-293T cells stably expressing a RBP-JΚ response element coupled to a firefly luciferase were used as a readout for active Notch signalling
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