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Engineered ubiquitin ligase PTB-U-box targets insulin/insulin- like growth factor receptor for degradation and coordinately inhibits cancer malignancy

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Academic year: 2020

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Figure

Figure 1: Generation of the engineered ubiquitin ligase. A, Schematic representation of the engineered ubiquitin ligases
Figure 2: Engineered ubiquitin ligases promote the ubiquitination and degradation of IGF-1R and IR
Figure 3: PTB-U-box inhibits cancer cell proliferation and invasion. A and B, HeLa and HepG2 cells were transfected with the indicated constructs, and cell growth was measured by MTT assay for 5 days
Fig.2C, expression of PTB-U-box markedly shortened
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