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Is it time to change the reference genome?

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Figure

Fig. 1 The reference genome is a type specimen.distributions of allele frequencies for variants called in 100 randomly chosen personal genomes, computed against the reference genome
Fig. 2 How consensus alleles improve the interpretability of the reference.genomes, computed against a consensus genome.personal genomes, computed against the reference, against an all-human consensus, the mean of the super-population consensuses and theme
Fig. 3 How-to reference. For future or new populations, sequencing is followed by building the consensus sequence from those genomes

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