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Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

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Figure

Figure 1: Potential drug targets in the Ubiquitin Proteasome System (UPS). Drugging the UPS has become a major research interest in recent years and several drugs targeting various components of the machinery are currently in clinical and pre-clinical deve
Figure 2: p53-MDM2 negative feedback loop. In response to its activation the tumour suppressor p53 leads to expression of a number of target genes including its key regulator MDM2
Table 1: E3 ligase inhibitors and method of identification
Figure 3:Regulation of the HECT E3 ligase Itch Itch is an important negative regulator of the transcription factors p63 and p73 leading to their polyubiquitination and subsequent proteasomal degradation
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