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The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor suppressive immunomodulatory transcripts

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Figure

Fig. 1 Outline of the screening strategy identifying the RBP SORBS2 as a key suppressor of metastatic colonization of ovarian cancer.cancer dataset.eSORBS2 high and SORBS2 low groups in TCGA dataset
Fig. 2 SORBS2 depletion promotes ovarian cancer metastasis. a Western blot analysis for SORBS2 in whole-cell lysate of A2780s cells expressingeither of two independent shRNAs targeting SORBS2 or a control shRNA
Fig. 3 SORBS2 depletion affects the stability of transcripts directly bound by SORBS2.( a Distribution of SORBS2 RIP sequencing peak annotationfor different regions
Fig. 4 SORBS2 depletion destabilizes transcripts ofexpressing high ( WFDC1 and IL-17D, which are correlated with clinical outcome in ovarian cancer
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