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Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

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Figure

Figure 1: Chemical structure of EC-70124 and anti-tumor action in vitro and in vivo. A
Figure 2: Effect of EC-70124 on signaling routes and kinase inhibitory profile. A. Expression of activated signaling proteins in BT549 and HS578T; and effect of EC-70124 on their phosphorylated status
Figure 3: Cell cycle analyses and effect on apoptosis of EC-70124. A, B. Effect of EC-70124 on cell cycle in HS578T, MDA-MB-231 and BT549 (A) and graphical representation (B) Cells were cultured in DMEM 10% FBS and treated with 500 nM EC-70124
Figure 4: Gene-set enrichment analyses of EC-70124. A, B, C, D. Network representation of enriched gene-sets (p-value <= 0.025 and a FDR < 0.25), deregulated by EC-70124 at 500 nM including gene-sets associated with DNA damage, translation and regulation o
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