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Regulatory effect of calcineurin inhibitor, tacrolimus, on IL 6/sIL 6R mediated RANKL expression through JAK2 STAT3 SOCS3 signaling pathway in fibroblast like synoviocytes

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Academic year: 2020

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Figure 1 The effect of the IL-6/sIL-6R complex on RANKL, JAK2, STAT3 in fibroblast-like synoviocytes (FLS)IL-6 and sIL-6R at several different concentrations (0, 30, 50, 100 ng of both) for 30 minutes induced RANKL protein expression in a dose-dependent ma
Figure 2 The therapeutic effect of tacrolimus on inflammation and bone erosion in a serum-induced arthritis mouse modelmRNA expression in the affected joints of mice with serum-induced arthritis (serum-induced arthritis was reversed with treatment by tacro
Figure 3 Regulatory effect of tacrolimus on RANKL and OPG expression in FLS under IL-6/sIL-6R stimulationanti-inflammatory drugs such as methotrexate (1 µg) and dexamethasone (1 µg)
Figure 4 The effect of tacrolimus on JAK2, STAT3, and SOCS3 in IL-6/sIL-6R-stimulated FLSboth) induced phosphorylation of JAK2 and STAT3
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