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The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation

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Figure

Figure 1. (A) Schematic of hydroxyapatite particles. (B) HA internalization by BMDCs. SEM images of BMDCs incubated with N5, R20 and S20 particles for 18 h
Figure 2. Hydroxyapatite particle size and shape dictates cytokine production by murine BMDCs
Figure 3. Hydroxyapatite particle shape dictates cytokine production by murine BMDMs. BMDMs (1.0 cells · ml× 106 −1) from C57BL/6 mice were stimulated with particles at concentrations ranging from 0.4 mg · ml−1 to 1 mg · ml−1 alone or after priming with LP
Figure 4. Hydroxyapatite particle-induced IL-1measured by ELISA. Data are shown as mean independent experiments (vs no inhibitor DPI (5–20 β production is NLRP3 dependent
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