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Metabolic flux control of mitochondrial dynamics in cancer cells

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Figure

Figure 1.1: Pathways that converge to produce ATP in mitochondria. Multiple cellular pathways converge from glycolysis, fatty acid synthesis and glutaminosis at the TCA to generate the electron carriers NADH and FADH2 that are then used at the ETC to creat
Figure 1.2: The function and molecular composition of ATP synthase. (A) Protons from the intermembrane space in high concentration enter the F0 region of ATP synthase, travel through a half-channel where they then bind to an aspartate residue
Figure 1.3: Fusion of two mitochondria to form one mitochondrion. Mitochondrial fusion required two types of proteins Mitofusin 1/2 and OPA1 for outer-membrane (OM) and Inner-membrane (IM) fusion, respectively
Figure 1.4: Fission of one mitochondrion to form two mitochondria. During fission, DRP1 is recruited from the cytosol to the outer mitochondrial membrane
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