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An investigation of kynurenine pathway metabolism, the hypothalamic pituitary adrenal axis, and inflammatory markers in Major Depressive Disorder

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Figure

Figure 1.1 Monoamine hypothesis and function of SSRI treatment.  (a) In the healthy brain, monoamine molecules are released by the presynaptic neuron and bind to monoamine receptors on the postsynaptic neuron; (b) In depression, it is hypothesised that few
Figure 1.2 Representation of the hypothalamic-pituitary-adrenal axis. In response to stress, the hypothalamus secretes CRH and AVP, which stimulate the production of ACTH from the anterior pituitary
Figure 1.3 Typical diurnal cortisol variation illustration. In healthy individuals, a 24-hour cycle of cortisol activity exists
Figure 1.4 Area under curve calculation. Illustration of an example area under curve (AUC) measurement
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