MassLynx TM 4.1 SCN 888
Release Notes
Page 1 of 36 Document No: 45943_1
INTRODUCTION: ... 3
SUPPORTED PRODUCTS/CONFIGURATIONS: ... 4
OPERATING SYSTEMS: ... 5
SECURITY: ... 5
SCN 888 INSTALLATION PROCEDURE: ... 6
Installation of Sample Manager Firmware 1.51 7 Installation of Stand–Alone Applications 8 Installation of Quanpedia databases 8 Adobe Print Driver Setup 8
MS ... 11
FEATURES: 11 CONCESSIONS: 11
INLETS ... 14
ENHANCEMENTS: 14 CONCESSIONS: 14
APPLICATIONS ... 15
FAULT FIXES: 15 CONCESSIONS: 15 INFORMATIONAL: 16
SUPPORTED COMPUTERS, OPERATING SYSTEMS, HOT FIXES AND ANTI-VIRUS SOFTWARE: ... 18
Windows 7.0 64 Bit Professional SP1 18 Windows Updates for Windows XP SP3 21 ANTIVIRUS 21 WINDOWS UPDATES 21
INSTALLING ACQUITY DRIVER COMPONENTS... 22
MassLynx Software Change Note #888
Introduction:
MassLynx Software Change Note #888 provides support for the ACQUITY QDa Detector.
The ACQUITY QDa Detector is a mass detector designed as a synergistic element of a chromatographic separations system. The ACQUITY QDa Detector is purposefully designed for analytical scientists who need mass spectral data without the complexity of a mass spectrometer, to confirm compound identity and quantify compounds with no or low UV response. With the on/off simplicity that analytical scientists have long wanted from mass spectrometry, the ACQUITY QDa Detector fully automates sample analysis and eliminates sample-specific adjustments, for certainty in sample results, from user to user and system to system. With the robustness and reliability demanded for use in routine laboratories, the ACQUITY QDa Detector brings the high quality mass spectral data expected from a
traditional single quadrupole mass spectrometer in a mass detector no bigger than the familiar PDA detector.
Supported Products/Configurations:
MassLynx 4.1 SCN 888 supports the following configurations:
MS LC / Inlets
(ICS Supported with SCN 888) ACQUITY QDa
Detector ACQUITY UPLC Systems
ACQUITY Binary Solvent Manager (ICS version 1.50.1521) ACQUITY Sample Manager (ICS version 1.50.2736)
ACQUITY Sample Organizer and CPSO (included in Sample Manager ICS)
ACQUITY PDA Detector (ICS version 1.50.1121) ACQUITY TUV Detector (ICS version 1.50.2530) ACQUITY ELS Detector (ICS version 1.40.1882) ACQUITY FLR Detector (ICS version 1.40.2407) ACQUITY Column Manager (ICS version 1.51.1684) ACQUITY Open Architecture System (BSM and 2777)
ACQUITY Isocratic Solvent Manager (ICS version 1.50.1134) ACQUITY UPLC H-Class and I-Class Systems
ACQUITY Sample Manager FTN (ICS version 1.50.1481)
ACQUITY Quaternary Solvent Manager (ICS version 1.50.1621) ACQUITY Isocratic Solvent Manager (ICS version 1.50.1134) ACQUITY Binary Solvent Manager (ICS version 1.50.1521) ACQUITY UPC2
ACQUITY Convergence Manager (ICS version 1.50.1185) ACQUITY UPC2 BSM (ICS version 1.50.1708)
ACQUITY QDa
Detector Waters 2777 Autosampler
Waters 2695 (controlled via GPIB) Waters 2996 PDA
ACQUITY QDa
Detector LC Purification Waters 2767 SM Waters 515 pump Waters SFO Waters 2545 BGM Waters 2998 PDA Waters 2489 UV ACQUITY QDa
Detector SFC
Waters 2545 QGM C02/Cosolvent Waters 2767 SM
Waters 515 pump Waters 2998 PDA ACQUITY QDa
Detector eAlliance - controlled via GPIB
Operating Systems:
Microsoft Windows XP Professional SP3
Microsoft Windows 7 Professional 64 bit, Service Pack 1
Note: There are several places in this document that refers to files and folders that are contained in the “Program Files (x86)” folder which is Windows 7 specific.
For Windows XP installations it can be read as simply “Program Files”
Security:
No MassLynx security configurations are supported.
SCN 888 Installation Procedure:
MassLynx 4.1 SCN 888 is a complete installation of MassLynx 4.1. If MassLynx or any MassLynx SCNs are already installed they must be uninstalled, by using the Windows
‘Add/Remove Programs’ (on Windows XP) or the ‘Programs and Features’ (on Windows 7) facility in the Windows Control Panel, before installation of MassLynx 4.1 SCN 888.
Please make sure that the “C:\Program Files (x86)\Micromass Utilities\ICOP” folder is deleted if present after un-installation.
1. Close MassLynx and any other software applications.
2. If any instrument drivers - such as ACQUITY drivers, Waters 2777 / CTC drivers - have been installed they must be removed, by using the Windows ‘Add/Remove Programs’ (on Windows XP) or the ‘Programs and Features’ (on Windows 7) facility in the Windows Control Panel, before installing SCN 888.
3. If MassLynx (including V4.1) is installed, it should be removed, by using the Windows ‘Add/Remove Programs’ (on Windows XP) or the ‘Programs and Features’
(on Windows 7) facility in the Windows Control Panel, and the PC should be rebooted after the removal is complete.
4. Manually delete the "C:\Program Files (x86)\Micromass Utilities\ICOP" folder prior to installation of SCN 888.
5. Install MassLynx V4.1 SCN 888 following the installation instructions starting at step 6 below.
6. Select Start–>Run from the windows start menu and type:
• <DVD–Drive>:\setup <return>
• Where, <DVD–DRIVE> is the drive letter of the DVDROM.
7. Follow the instruction of the program.
8. Click Finish to complete installation of the SCN files.
9. Reboot the PC and log back into windows.
10. Reboot the instrument embedded PC.
11. Launch MassLynx once the instrument front panel status LED is no longer flashing amber.
12. Open Inlet Editor.
13. Install any required Waters instrument drivers (ICS) using the Deployment Manager by clicking “Setup Instruments”. If any drivers are installed it is recommended that the PC is rebooted afterwards before continuing the inlet system configuration.
14. Click “Configure” to launch the Inlet Configuration Dialog to complete the configuration of the inlet system.
Note: Modifying or repairing an installation is not supported.
Note: OpenLynx, TargetLynx and QuanOptimize are included on all installations of SCN 888.
Note: Instructions for installing the ACQUITY Components can be found in the
‘Installing ACQUITY Driver Components’ section, this will include configuration of
Installation of Sample Manager Firmware 1.51
1. Check which sample manager firmware version is installed on your system. If it is not ACQUITY UPLC Sample Manager firmware version 1.50, do not install firmware version 1.51.
2. Reboot the sample manager.
Tip: If also installing sample organizer firmware, deconfigure the sample organizer or power off the sample manager.
3. Run the self-extracting ZIP file located at C:\Program Files (x86)\Micromass Utilities\ICOP\Updated Firmware\ and unzip the files to the following location:
• C:\Program Files (x86)\Waters Instruments\Firmware 4. When asked to overwrite files, choose Yes.
5. Navigate to the location you selected in step 3, and run Loader.exe.
6. In the Welcome page, select Scan for instruments.
7. Select the instrument you are updating, and then click OK - The ‘Select the File to Load’ window opens.
8. In the Select the File to Load window, click Browse to find and select the appropriate .sft file from the location you selected in Step 3:
• For an ACQUITY UPLC Sample Manager, select “ACQUITY Sample Manager.sft”
• For an ACQUITY UPLC Sample Manager - FL, select “ACQUITY Sample Manager FL.sft”
• For an ACQUITY UPLC Sample Manager - FTN, select “ACQUITY Sample Manager FTN.sft”
• For an ACQUITY UPLC Sample Organizer, select “ACQUITY Sample Organizer.sft”
9. Click Next to begin loading the firmware.
10. When firmware loading is 100% complete, click Finish, and then reboot the sample manager.
Further information can be found in the Sample Manager release notes which can be found in the following location on the installation:
<DVD–Drive>:\716003649rA.pdf
(Where <DVD–DRIVE> is the drive letter of the DVDROM.)
Installation of Stand–Alone Applications
This instruction is for installation of OALogin, OAToolkit, OpenLynx Browser and TargetLynx Browser.
If any of these applications are already installed they must be removed, by using the Windows ‘Add/Remove Programs’ (on Windows XP) or the ‘Programs and Features’ (on Windows 7) facility in the Windows Control Panel, before installing the SCN 888 version.
1. Close any open software applications.
2. Insert the MassLynx SCN 888 DVD into the DVD–ROM drive.
3. Navigate to the Applications folder on the DVD and select the folder for the Application required.
4. Run setup.exe
5. Follow the instruction of the program.
6. Click Finish to complete installation of the SCN 888 files.
Installation of Quanpedia databases
Example databases are available on a separate CD. These example databases should be copied onto the PC and can then be opened in Quanpedia by selecting Options | Database | Open.
Files copied from a CD may have the read-only flag set and this will need to be removed.
To manually remove the read-only attribute from a file:
1. In Windows Explorer, right-click the file that you want to change, and then click Properties.
2. On the General tab, click to clear the Read Only check box.
3. Click OK.
Adobe Print Driver Setup
“Print to PDF” options in MS Console and MS Method Editor require the Adobe PDF print driver to be installed. This driver is part of Adobe Acrobat Distiller, which is included in Adobe Acrobat Professional. The recommended and validated version of Acrobat
Professional to work alongside MassLynx is Adobe Acrobat Professional 9.0. Please install this version of Acrobat Professional before attempting to use MassLynx “Print to PDF”
options.
Software setup:
• Log in as an administrator and install ‘Adobe Acrobat 9’ using the default setup options. A restart may be required.
• Once installation is complete, double click the 'Adobe Acrobat 9 Standard' link on your desktop.
• Read and accept the license agreement, then close the 'Adobe Acrobat' window.
The following steps apply to each user account on the host PC:
• View installed printers from the Windows Control Panel.
o Adobe PDF Security: as appropriate
o Adobe PDF Output Folder: Prompt for PDF filename o Adobe PDF Page Size: as appropriate
• Ensure only the following boxes are checked:
o Rely on system fonts only; do not use document fonts o Delete log files for successful jobs
• Press Apply and OK
Note: To configure PDF printing for OALogin, the 'Adobe PDF Output Folder' must be set to the OALogin ReportDB directory (normally C:\MassLynx\OALogin\ReportDB).
SCN 888 Un-installation:
MassLynx can be removed by using the Windows ‘Add Remove Programs’ (on Windows XP) or ‘Programs and Features’ (on Windows 7) facility in the Windows Control Panel.
MS
General Note(s):
SCN 888 is solely for the ACQUITY QDa detector. Historic features of MassLynx have been amended to work in conjunction with the new features and abilities of the ACQUITY QDa detector.Features:
The following table contains a list of software features included in SCN 888.
Automated mass calibration and resolution verification for consistent data quality.
Automatically-optimized single ion recording (SIR) and full scan (FS) analysis for enhanced data acquisition.
Automated acquisition with reduced parameter set for enhanced usability.
Concessions:
The following table contains a list of known software issues and workarounds for SCN 888.
General
MassLynx will hang if user selects “Network” from the “Print Setup” dialog box. Printers must be configured in the operating system first, as they will then be available in MassLynx “Print Setup” without needing to click “Network”.
By design a non-admin user cannot adjust date and time settings.
Non OS Admin users cannot run ACQUITY Plot Viewer from C:\Program Files (x86)\Waters Instruments\Bin folder.
To install ICS instruments older than 1.4 the ICSCompanionSetup.exe should be run manually.
It is recommended that if removing some ICS instruments and not replacing with others, then the ICS should not be removed, the instruments should only be de-configured from MassLynx and the console.
Careful consideration should be given when setting up shut down methods. MS shutdown actions should be placed after LC shutdown actions in MS error methods to ensure that LC actions are able to complete even if MS communication is not available.
LC shutdown actions should be placed after MS shutdown actions in LC error methods to ensure that MS actions are able to complete even if LC communication is not available.
On rare occasions during the install, an error message is displayed stating that the DHCP Server failed to register. If this message is seen, the installation should be cancelled and then started again.
On rare occasions during an uninstall of MassLynx, an error message is displayed stating
“Waters DHCP error - 'Could not delete service'”. If this message is seen it should be acknowledged and after the process has completed the PC should be rebooted before attempting a further install.
A sample list batch can not be modified once it has been submitted.
Desktop only install – an incorrect error message stating "Failed to create new project"
will be displayed when creating a new project, it can be ignored as the project will be created as required.
If using OA Login Autopurification - AutoLynx is no longer required to handle multi-stage AutoPurify runs, this functionality is now handled by Process Manager.
When changing between different Windows users, the user should log off and the new user should log on. Utilising the ‘Switch users’ option can introduce instability to the instrument.
The Rear Panel Event Out 2 will not pulse, it will only allow the output to be closed or opened when triggered.
If a Source Pressure Test fails during the startup process then the Critical Readback Check will not be carried out. If the Critical Readback Check had previously failed, it will still show as having failed once the Source Pressure Test has passed. At this point the instrument will need to be power cycled to allow for a new Source Pressure Test
Console
The console needs to finish loading before any options are selected. Closing the console before this point can cause it to enter into an error state.
Occasionally when opening the console for the first time, the console plots will not display. Closing and reopening the console will display the plots as expected.
The console plots can occasionally fail to update, the instrument data collection is not affected and the plots will resume as normal after a short period.
Clicking between the ACQUITY log entries can cause an error in the Console.
Cancelling a print of the ACQUITY logs can cause an error in the Console.
Printing from the ACQUITY logs will print all entries, to print a single log, it should first be printed to PDF and then the relevant log selected.
During a run the Operate button will not be disabled
MS Method Editor
MS Methods created on a previous version of MassLynx are not compatible with the QDa Detector.
Method Event initial settings should be used for events which are to occur at a time 0.0, if the required event is not available in the initial settings it should be set to a time of 0.01.
In the MS experiment window when creating an SIR method, when a new function is added, MassLynx will order the functions in order of mass. This is correct. However if the mass in an existing function in the list is changed and resaved, the method does not reorder the list of SIRs so that the masses are running in order of mass. To correct this issue, delete the line that is to be changed and create a new one with the correct mass in it.
Startup/Shutdown Control
The following task items are not applicable to the QDa Detector:
APPI Lamp on APPI Lamp off Ion Mode MS Event Out 3 MS Event Out 4 Reset
Stop Flow Syringe Pump Tune Page
To assign a StopFlow event from the tasklist, the ‘Stop LC Flow’ option should be utilised or ‘Turn API gas off’.
OpenQuan
In OpenQuan, using the 'Specify OpenQuan results location' option requires a fully- qualified network path to be used when samples are logged in (e.g.
\\<PC_Name>\Results\ where <PC_Name> is the IP address or computer name of the PC on which the results will be stored)
INLETS
Enhancements:
The following table contains a list of software enhancements included in SCN 888.
A new version of the driver for Waters 2777 / CTC PAL has been included, version 1.6.0.3, which is automatically installed when MassLynx is installed. There is no longer any need to manually install the driver.
The CTC barcode reader on Waters 2777 / CTC PAL systems is supported.
Concessions:
The following table contains a list of known software issues and workarounds for SCN 888.
General
When installing Inlet drivers it is recommended that QDa users utilise the custom option to allow them to deselect the ACQUITY components which are not supported by this instrument (see Supported Products/Configurations section above), rather than utilising the default option which is to install all drivers.
During inlet configuration, Waters deployment manager does not automatically launch when required. Each ACQUITY component should be setup manually before configuring them in the inlet editor using the "Setup Instrument" button in the inlet configuration window.
It is recommended that users do not use a higher scan rate than 1 scan per sec with the Waters 2996 detector.
When running ACQUTY Open Architecture System, the column temperature data channel should be enabled in the ACQUITY Column Manager method.
'Fill Series in the sample list does not work when using the Waters 2777 with Alphanumeric Referencing'.
The first time an ACQUITY system is initialized an error message about an ACQUITY server may pop up. This can be safely ignored.
When installing components via the Inlet Editor, the ACQUITY Console should not have previously been opened since the PC was restarted. Users should restart the PC and then install new components without opening the Console before installation.
On opening the Inlet Editor for the first time, the message ‘Loading old bgm method. Its version will be updated, continue?’ may be shown. Users should ok this message to continue past, it will not cause an issue with the instrument.
Waters Pump Control should be removed via the deployment manger prior to the removal of MassLynx.
To stop the flow of an ISM via the inlet control, the button needs to be pressed twice in quick succession.
Software Stop Flow is only applicable to ACQUITY Systems, non- ACQUITY inlets should utilise a hardwire from the StopFlow output Event on the rear panel.
APPLICATIONS
Fault Fixes:
The following table contains a list of fault fixes included in SCN 888.
TargetLynx
The option to print separate samples is now in the Report Format.
TargetLynx now displays integrated peaks when Mass A, Mass B etc. are specified as the trace in the TargetLynx Method Editor in the Quantification Trace field.
Concessions:
The following table contains a list of known software issues and workarounds for SCN 888.
TargetLynx
A modified calculated concentration column header will not be reflected in the samples report, it will remain with its default heading.
The following values will be blank when the indeterminate flag is set:- Calculated Concentration
% deviation
% Recovery LOD Flag LOD LOQ Flag LOQ
FractionLynx The auto-delay report cannot be saved.
In One for One collection mode, if multiple fractions is not enabled, there will be no warning to the user when injecting from the same tube and only the fraction from the first injection will be collected.
With XY configuration on the Rack Generator, the “horizontal priority” option should be left unchecked for injections which are to be performed row by row. The “horizontal priority”
should be selected for injections which are to be performed column by column.
After changing “horizontal priority” on the Rack Generator, if “fill series” is applied to the vial numbers in the sample list, the vial numbers may not appear in the correct order.
Applying “fill series” a second time will display the vials in the correct order.
Multiple staggered SIR functions are not supported in FractionLynx. It is recommended that all SIR functions have identical start and end times within the same method.
OpenLynx
Default.ipr should be utilised wherever the software requests an IPR file reference.
QuanOptimize
Pressing F1 to access help is not implemented for the following QuanOptimize applications (it can still be accessed by the main menu):
Edit Method
Run QuanOptimize View Results
Informational:
QuanOptimize
QuanOptimize is available to aid in compound optimization, however many features are not required for the QDa Detector. Where possible, these features have been disabled. The setup below should be followed on QDa Detector:
Open predefined sample list named AnalyticalList_QDa.spl from C:\MassLynx\Default.pro\Sampledb
Enter required details along with the Molecular Mass(es) of interest in the ‘Mass A’ Field and overwrite the Sample List ie save as AnalyticalList_QDa.spl
Open the QuanOptimize Method Editor by selecting Edit Method within the QuanOptimize tab.
Select the appropriate ion mode for the compound of interest by opening one of the following files:
· Optimize_Method_ESI_Both(PosNeg)_QDa.qlm – this optimizes positive and negative ion mode simultaneously. Note: The optimization range is limited compared to single polarity runs.
· Optimize_Method_ESI_Neg_QDa.qlm – this optimizes the compound(s) of interest in negative ion mode.
· Optimize_Method_ESI_Pos_QDa.qlm – this optimizes the compound(s) of interest in positive ion mode.
be used as the basis for the SIR Method creation.
Enter an appropriate Injection volume for your sample, save (overwrite) the opened method and exit the QuanOptimize Method Editor.
Start QuanOptimize by selecting Run QuanOptimize from the QuanOptimize tab and select the *.qlm that was edited above and enter a Unique Batch name, press Finish to start the Optimisation process.
The process will result in the creation of an optimised SIR Method File *.exp for each of the Compounds of Interest entered in to the AnalyticalList_QDa.spl. The created Methods will be named ‘MS_<Compound A>.exp which can be found in the C:\MassLynx\<working project>.pro\Acqudb folder.
Refer to the relevant sections of QuanOptimize help for further details.
Supported Computers, Operating systems, Hot fixes and Anti-Virus software:
MassLynx 4.1 SCN 888 was tested and validated with Lenovo ThinkStation C30 workstations on Microsoft Windows 7 Professional 64 Bit, Service Pack 1
MassLynx 4.1 SCN 888 was tested and validated with Lenovo ThinkStation C20X workstations on Windows XP Professional SP3
The following Windows Updates are supported with MassLynx v4.1 SCN 888:
Windows 7.0 64 Bit Professional SP1 Description HotFixID
Update 982861 Update KB2592687
Update KB971033
Security Update KB2393802 Security Update KB2425227 Security Update KB2476490 Security Update KB2479943 Update KB2484033 Update KB2488113 Security Update KB2491683 Update KB2492386 Hotfix KB2496898 Security Update KB2503665 Update KB2505438 Update KB2506014 Security Update KB2506212 Update KB2506928 Security Update KB2507618 Security Update KB2509553 Update KB2511250 Security Update KB2511455
Update KB2515325 Update KB2522422
Update KB2529073 Security Update KB2532531 Update KB2533552 Update KB2534366 Security Update KB2536275 Security Update KB2536276 Update KB2541014 Security Update KB2544893 Update KB2545698 Update KB2547666 Hotfix KB2550648 Update KB2552343 Security Update KB2555917
Update KB2563227 Security Update KB2563894 Security Update KB2564958 Security Update KB2567680 Update KB2570791 Security Update KB2570947 Update KB2574819
Security Update KB2579686 Security Update KB2584146 Security Update KB2585542 Update KB2603229 Security Update KB2604115
Update KB2616676 Security Update KB2618451 Security Update KB2619339 Hotfix KB2619497 Security Update KB2620704 Security Update KB2620712 Security Update KB2621440 Security Update KB2631813 Update KB2640148 Security Update KB2644615 Security Update KB2645640 Security Update KB2647518 Update KB2647753 Security Update KB2653956 Security Update KB2654428 Security Update KB2655992 Security Update KB2656356 Security Update KB2656411 Security Update KB2658846 Security Update KB2659262 Update KB2660075 Security Update KB2660649 Update KB2661254 Security Update KB2667402 Security Update KB2676562 Update KB2677070 Update KB2685811 Update KB2685813 Security Update KB2685939 Security Update KB2688338 Security Update KB2690533 Security Update KB2691442 Security Update KB2698365 Update KB2699779 Security Update KB2705219 Security Update KB2706045 Update KB2709630 Update KB2709981 Security Update KB2712808 Security Update KB2716513 Update KB2718704 Security Update KB2719033 Update KB2719857
Security Update KB2719985 Security Update KB2724197 Update KB2726535 Security Update KB2727528 Update KB2729094 Security Update KB2729452 Update KB2731771 Security Update KB2731847 Update KB2732059 Update KB2732487 Update KB2732500 Update KB2735855 Update KB2736233 Security Update KB2736422 Update KB2739159 Update KB2741355 Security Update KB2742599 Security Update KB2743555 Security Update KB2744842 Update KB2749655 Update KB2750841 Security Update KB2753842 Update KB2756822 Security Update KB2756921 Security Update KB2757638 Security Update KB2758857 Update KB2761217 Security Update KB2761465 Update KB2762895 Update KB2763523 Security Update KB2769369 Security Update KB2770660 Update KB2773072 Security Update KB2778344 Security Update KB2778930 Update KB2779562 Security Update KB2785220 Update KB2786081 Update KB2786400 Security Update KB2789645 Security Update KB2790113 Security Update KB2790655 Security Update KB2792100 Security Update KB2797052 Update KB2798162 Security Update KB2799494 Security Update KB2804579 Security Update KB2807986 Security Update KB2813170 Security Update KB2813347 Security Update KB2813430
Security Update KB2840149 Security Update KB2845690
Update KB958488 Update KB976002
Update KB976902
Update KB982018
Windows Updates for Windows XP SP3
Windows XP Windows Malicious Software Removal Tool - November 2010 (KB890830) Windows XP Security Update for Microsoft .NET Framework 1.1 SP1 on Windows XP, Windows Vista, and Windows Server 2008 x86 (KB2416447)
Windows XP Security Update for Microsoft .NET Framework 3.5 SP1 on Windows XP, Windows Server 2003, Windows Vista, Windows Server 2008 x86 (KB2416473) Windows XP Security Update for Microsoft .NET Framework 2.0 SP2 and 3.5 SP1 on Windows Server 2003 and Windows XP x86 (KB2418241)
Windows XP Security Update for Windows XP (KB2360937) Windows XP Security Update for Windows XP (KB2279986) Windows XP Security Update for Windows XP (KB981957) Windows XP Security Update for Windows XP (KB982132) Windows XP Security Update for Windows XP (KB2387149) Windows XP Security Update for Windows XP (KB2378111)
Windows XP Cumulative Security Update for Internet Explorer 7 for Windows XP (KB2360131)
Windows XP Update for Windows XP (KB2345886)
Windows XP Security Update for Windows XP (KB2296011) Windows XP Security Update for Windows XP (KB979687) Windows XP Security Update for Windows XP (KB975558) Windows XP Update for Windows XP (KB2158563)
Windows XP Security Update for Windows XP (KB2347290) Windows XP Security Update for Windows XP (KB2121546) Windows XP Security Update for Windows XP (KB2124261) Windows XP Security Update for Windows XP (KB2290570) Windows XP Security Update for Windows XP (KB981322) Windows XP Security Update for Windows XP (KB2259922) Windows XP Update for Windows XP (KB2141007)
Antivirus
Symantec Endpoint Protection v12 (12.1.2015.2015) anti-virus software is supported. It is recommended that Network Threat Protection is disabled on the Acquisition PC.
Windows Updates
The PC firewall can occasionally be re-enabled by windows updates; after every update the firewall should be checked to ensure it is still disabled.
Installing ACQUITY Driver Components
This instruction is for installation of ACQUITY Driver Components.
1. Ensure the MassLynx console is closed before running the Waters Deployment Manager.
2. From the MassLynx inlet editor select Tools | Instrument Configuration…
3. Select the ‘Setup Instrument’ button to launch the Waters Deployment Manager.
4. Choose the Install / Upgrade option
5. After accepting the Waters licence agreement chose the Custom option.
Important note: The Typical option will install all driver packs which can cause issues with the ISM configuration under MassLynx Inlet editor.
6. By default all the driver packs are selected.
7. Use the ‘Invert’ button to deselect them all.
8. Select the required driver packs for your ACQUITY system e.g.
9. When installing the Isocratic Solvent Manager, the Waters Pump Control Software pack must also be chosen.
10. Review the components to be installed and ensure that the correct driver pack is selected for the hardware to be configured e.g.
11. Allow all chosen driver packs to install.
12. Select ‘Finish’ to close the Waters Deployment Manager and launch the firmware Autoloader tool.
Note: The QDa firmware will not be recognised by the loading tool. This is normal and should be ignored. Ensure all ACQUITY modules and Isocratic Solvent Manager has the ‘Current’ firmware loaded.
13. Select OK to close the firmware Autoloader tool and select ‘Yes’ to reboot the Host PC.
14. Exit MassLynx when prompted and allow the Host PC to be restarted.
15. After the Host PC has restarted, power cycle the ACQUITY equipment and allow approximately 30 seconds for each unit to be allocated an IP address by the Waters DHCP service.
16. Launch MassLynx and open the MS Console. Ensure all ACQUITY equipment installed and powered up is present in the console. There should be no communication errors reported to any of the equipment.
17. From MassLynx launch the Inlet Editor and select Tools | Instrument Configuration…
19. For the pump chose the ‘Waters Pump Control’ option
20. Select the appropriate sample manager
Configuring a PDA or TUV Detector
21. If using a PDA or TUV detector then add it to the list
22. Before selecting the appropriate detector, press the ‘Scan For Instruments’ button
23. This will open the Waters Instrument Scan box that will populate with all available instruments. Press OK to close this box when the appropriate detector is listed.
24. The ACQUITY PDA of TUV will now be selectable in the list
25. Select ‘Finish’ to close the wizard.
26. Select ‘Finish’ again to close the Inlet Configuration
27. At this stage there will be a communication error flagged in the Inlet Editor status.
This is normal and the following steps should be taken to configure the Isocratic Solvent Manager for communication.
28. Press the ‘Inlet’ icon to open the pump method configuration.
29. At the bottom of the editor select the ‘Config’ button.
30. Before attempting to configure any pump, select the ‘Scan’ button. This will display a list of the available ACQUITY hardware. Close the dialog box once this is populated.
31. When using the Isocratic Solvent Manager with an existing ACQUITY pump, configure both pumps as appropriate selecting the corresponding instrument addresses as shown below.
32. Press ‘OK’ to complete the configuration and ‘OK’ again to dismiss the reset communication message box.
33. Method configuration should now be available for both pumps.
34. Close the method configuration and select LC | Reset Communications from the Inlet Editor to clear the error state. Full communication should now be established with the Isocratic Solvent Manager through the Inlet Editor and normal MassLynx operation can be resumed.