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FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation

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Figure

Figure 1: the cPD motif of FAAP20 regulates FAAP20 degradation. A. FAAP20 is the protein with a short half-life
Figure 2: FbW7 is required for proteasomal degradation of FAAP20. A.wild-type or HeLa cells transfected with increasing levels of the FBW7-encoding plasmid were analyzed by Western blotting
Figure 3: FbW7 induces FAAP20 polyubiquitination and degradation. A. FBW7 interacts with FAAP20
Figure 4: Phosphorylation of FAAP20 by GSK3β mediates FAAP20 degradation. A.type or SA mutant were analyzed by Western blotting
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