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Neuronal network dysfunction precedes storage and neurodegeneration in a lysosomal storage disorder

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Academic year: 2020

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Figure 1. Activation of the DG after PP stimulation is significantly decreased in CLN3followed by Tukey’s multiple-comparisons test)
Figure 2. Activation of the CA3 and CA1 after perforant path stimulation are significantly decreased in CLN3fluorescence change in the hilus and CA3 regions supports hypoexcitability in mice by 6 and 18 months of age, respectively
Figure 3. As CLN3 disease progresses, CA1 becomes hyperexcitable in response to SC stimulation
Figure 4. All regions of the hippocampus have a decrease in correlation of activity that begins in early-stage CLN3 disease
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