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Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway

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Figure

Fig. 1 Simplified overview of one-carbon metabolism pathway.methylenetetrahydrofolate dehydrogenase 1; MTHFR, methylene tetrahydrofolate reductase; MTHFD1, MTR, methionine synthase; MTRR, methionine synthasereductase; RFC1, reduced folate carrier 1;BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine beta synthase;SHMT, serine hydroxymethyltransferase; AdoHcy, S-adenosylhomocysteine; AdoMet, S-adenosylmethionine
Table 1 Distribution of biological makers of folate metabolismin cases and controls
Table 3 Genotype and allele frequencies of the MTHFD1 G1958A polymorphism in case and control groups
Table 4 Genotype and allele frequencies of the MTHFR C677T polymorphism in case and control groups
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