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Candidate genes for antidepressant response to selective serotonin reuptake inhibitors.

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Figure

Table 1 Strategies for selecting candidate genes forantidepressant response
Figure 1 Potential cascade of events mediating and moderating SSRI effects. The multiple inter-regulatory and feedback pathways are absent from this figure.Abbreviations: BDNF, brain-derived neurotrophic factor; COMT, catecholamine-O-methyl-transferase; CRH, corticotropin-releasing hormone; CRH2, CRHreceptor2; cAMP, cyclic adenosine monophosphate; CREB, cAMP response element binding protein; DARPP-32, dopamine and cAMP regulated phosphoprotein;DAT, dopamine transporter; MAOA, monoamine oxidase A; NOS, nitric oxide synthase; NET, norepinephrine transporter; 5-HT, serotonin; SERT, serotonin transporter;SSRI, selective serotonin reuptake inhibitor; TPH, tryptophan hydroxylase.

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