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Structure-based drug design: aiming for a perfect fit.

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Figure

Figure 1. Yearly growth of structures in the Protein Data Bank
Figure 2. CryoEM structure of the 20S proteasome with bound substrate analogueThe left-hand side shows a superposition of the cryoEM density map and 20S proteasome coordinates in orange (PDB accessioncodes EMD-2981 and 5A0Q)
Figure 3. Crystal structure of the chemical tool CCT251545 bound to the CDK8-cyclin C complexThe inhibitor CCT251545 is shown in gold, CDK8-cyclin C is displayed in purple and key hydrogen bond interactions are shown inyellow (PDB ID code 5BNJ).

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