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PAK Paradox: Paramecium Appears To Have More K+-Channel Genes than Humans

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Figure

FIG. 1. (A) Diagrams representing the topology of K�relative positions of the core elements, including the fifth and sixthtransmembrane segments (S5 and S6, respectively), the connectingpore helix (P), and the Kmost closely related to the PaK proteins
FIG. 2. ClustalW (Gonnet 250) alignment of PaK channel sequences. The alignment shows high similarity among the PAKtransmembrane segments (S5 and S6), the turret, pore helix, and filter are designated based on the apparent homology between the PaKtranslatio
FIG. 4. ClustalW (Gonnet 250) alignment of putative regulatory domain sequences. All PaK sequences that could be extended �downstream of S6 share a conserved stretch with homology to cyclic nucleotide binding domain sequences (reference numbers 14778, 9173
FIG. 5. Intron positions do not correlate with sequence similarity. (A) A distance tree highlights the relatedness of several closely related groupsof PaK translations

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