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A Metabolome- and Metagenome-Wide Association Network Reveals Microbial Natural Products and Microbial Biotransformation Products from the Human Microbiota

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Figure

FIG 1 The pipeline includes the following steps: extracting microbial (a) and molecular (b) features from the raw data, searchingfor pairs of associated features and computing false discovery rates (c), constructing the association network (d), and assigningmolecular features to phylogenetic clades (e).
FIG 2 (a) Microbial natural products can be detected as positive correlations between the occurrences of the microbial species and the molecules inthe association network
FIG 4 (a) Chemical structure of corynomycolenic acid. (b) Metabolite graph of corynomycolenic acid
FIG 5 BGC of phevalin. (a) Putative nonribosomal peptide synthetase (NRP) BGC discovered by antiSMASH
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