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Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells

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Academic year: 2020

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Figure 1. Effect of exogenous spexin on body weight, blood parameters, and HOMA-IR in HFD-induced SD rats
Figure 2. Glucose metabolism parameters of HFD-induced IR rats in the hyperinsulinemic-euglycemic clamp test and liver morphology shown by H&E staining.in the HFD + spexin group were remarkably lower than that in the HFD group
Figure 3. Expression of Akt, CREB, FoxO1, PGC-1, PEPCK, and G-6-Pase in the liver tissues of rats
Figure 4. Spexin inhibited gluconeogenesis in a dose- and time dependent manner in an IR cell model
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