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Khz cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase dependent generation of reactive oxygen

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Figure

Figure 1 (See legend on next page.)
Figure 2 Khz-cp induces apoptosis through a mitochondrial pathway. (A) SNU-1 cells were treated with a 1:100 dilution of Khz-cp, andcaspase or PARP activation was analyzed by immunoblotting
Figure 3 (See legend on next page.)
Figure 3 Khz-cp triggers cytoplasmic and mitochondrial ROS generation. (A) SNU-1 cells were loaded with H2DCF-DA and treated withKhz-cp (diluted 1:100), and the cytoplasmic ROS levels were assessed by flow cytometry
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