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Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

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Academic year: 2020

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Figure

Figure 1ACPAs are linked to high bone resorption in humans. Serum samples obtained from healthy controls as well as patients with RA without ACPAs
Figure 2Isolation of ACPAs from human serum. (A) ACPA reactivity of the original serum from RA patients, purified ACPAs, the corresponding Fab frag-
Figure 3Expression of PAD enzyme and citrullinated vimentin in osteoclasts. (A and B) Real-time PCR for PAD2 (A) and PAD4 (B) of human osteoclast
Figure 4MCV-ACPAs stimulate osteoclastogenesis. (
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