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IL 12 upregulates TIM 3 expression and induces T cell exhaustion in patients with follicular B cell non Hodgkin lymphoma

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Figure

Figure 1IL-12 serum levels and their correlation with survival in FL. (A) IL-12 serum levels in untreated FL patients (FL, average: 0.56 ± 0.05 ng/ml, n = 30)  and healthy donors (HD, average: 0.39 ± 0.049 ng/ml, n = 22, P = 0.017)
Figure 2Frequency of TIM-3–expressing CD11cperipheral blood (from healthy individuals (upper panels) or FL patients (lower panels)
Figure 3Function of TIM-3–expressing T cells CD8was measured by intracellular stain-ing in intratumoral T cells stimulated with PMA/ion in the presence of brefeldin A (IL-6, IL-12, or IL-2 and phosphoryla-tion of STAT1, -3, -4, or -5 was mea-sured by Phosf
Figure 4Coexpression of TIM-3 and PD-1 in FL. (
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