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Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?

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Figure

Figure 1: (A) Bcl-2 family member effector proteins (Bax and Bak) oligomerize and permeablize the outer mitochondrial membrane (OMM) upon activator-protein (Bid, Bim and Puma) binding
Table 1: Transgenic misregulation of Bcl-2 family proteins in mouse models of mammary development and breast tumorigenesis
Figure 2: (A) Transcriptional, translational and post translational mechanisms of Mcl-1 regulation (promoters support Mcl-1 expression, while deregulators decrease Mcl-1 expression)
Figure 3: Expression signature of Bcl-2 family proteins in human breast cancer cell lines according to the cancer cell line encyclopedia as curated by the cancer genome atlas

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