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MIA Sig: multiplex chromatin interaction analysis by signal processing and statistical algorithms

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Figure

Fig. 1 Performance of MIA-Sig onentropy of the expected null model.and 85,000 triplets, from which 15,055 complexes pass the second distance test.significant (upper triangle) complexes demonstrates that MIA-Sig removes off-diagonal noise.neighboring distan
Fig. 2 Enrichment test onare pronounced in regions with a high level of transcription, abundant loops, and active histone mark; insignificant complexes tend to be ininactive regions.10by retaining complexes with fragments in strong binding regions, which a
Fig. 3 Distance test results on SPRITE mouse embryonic stem cell dataset. a Of 487,679 complexes in chr18, 11,984 (2.46%) complexes pass bythe 2 distance tests
Fig. 4 Summary of MIA-Sig algorithm. ChIA-Drop putative complexes from ChIA-DropBox pipeline are inputs to the distance test, which assigns pvalues to each complex to quantify its significance
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