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NicE seq: high resolution open chromatin profiling

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Figure

Fig. 1 Nicking enzyme-mediated labeling of open chromatin.colocalization.intensity of the blue pixels ( a Nicking of crosslinked chromatin using varying amounts of Nt.CviPII
Fig. 2 NicE-seq using 25–250,000 cells for open chromatin profiling. a The number of total mapped reads and the number of peaks identifiedbefore and after normalizing the total mapped reads to the level of 250 cells
Fig. 3 NicE-seq and validation of NicE-seq in fixed and native cells. a The different steps involved in labeling and capture of open chromatin sitesusing NicE-seq
Fig. 4 Validation of open chromatin sites identified by NicE-seq. a A heat map showing the correlation of NicE-seq peaks in a ±3-kb window withoccupancy of H3K4me1, H3K4me3, H3K27ac, RNA pol II, and YY1 across ChIP-seq data from ENCODE for HCT116 cells
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