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CancerLocator: non invasive cancer diagnosis and tissue of origin prediction using methylation profiles of cell free DNA

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Figure

Fig. 1 Flowchart of CancerLocator. Step 1: A set of solid tumor samples and healthy plasma samples collected from public databases and theliterature are used to select the informative features (CpG clusters) that can differentiate tumor types or healthy pl
Fig. 2 The mixture model of methylation level (x) in a patient’splasma cfDNA for different burdens of ctDNAs from the tumor typet
Fig. 3 The predicted ctDNA burden for simulated normal andprediction with the true (cancer plasma samples
Table 1 Confusion matrix of prediction results on the real plasma samples
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