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FGF regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate

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Figure

Fig. 1. Wild-type mouse eyelid anatomy at E15.5. The componentsof the normal ocular epithelia are color coded: bulbar conjunctiva,purple; palpebral conjunctiva, pink; palpebral epidermis, dark red;periderm, orange; cornea, blue.
Fig. 3. Cell proliferation in Smad4bulbar conjunctiva; PC, palpebral conjunctiva; PE,palpebral epidermis
Fig. 4. Foxc1Fgfr2mRNA on frontal eye sections from wild-type (A), Smad4 and Foxc2 transcripts are greatly reduced inCKO and Smad4CKO eyelids
Fig. 6. Signaling from Fgfr2 promotes Bmp4, patched 1expression and BMP signaling in the eyelid.staining was greatly reduced in the palpebral conjunctiva (arrow)
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