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Small nerve fibre quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fibre density

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Figure

Table 2. AUC, 95% confidence interval values and sensitivity-specificity for manual and automated CCM for the diagnosis of DSPN
Fig. 1: Corneal confocal microscopy images of the subbasal nerve plexus from a control (a), T1D without DPN (b), and T1D with DPN (c) showing the reduction in corneal nerves in those with DSPN
Fig. 3: Immunohistochemical study (neuronal marker PGP9.5) in sections from skin biopsies from dorsum of the foot from a healthy subject (a), a patient with T1 diabetes without neuropathy (b), and with neuropathy (c)
Fig. 4:  Boxplot of (a) IENFD (b) Manual CNFD values (c) Automated CNFD values (d) Automated CNFL values grouped into controls, non-neuropathic and neuropathic groups, based on Toronto criteria
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