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Induction maintenance with tumour necrosis factor inhibitor combination therapy with discontinuation versus methotrexate monotherapy in early rheumatoid arthritis: a systematic review and meta analysis of efficacy in randomised controlled trials

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Figure

Table 1PICOS used to outline the research question
Figure 1Flow chart of studyselection. ERA, early rheumatoidarthritis; MA, meta-analysis; MTX,methotrexate; RCT, randomisedcontrolled trial; TNFi, tumournecrosis factor inhibitor; SR,systematic review.
Table 2Characteristics of the studies included in the meta-analysis
Figure 2Forest plot of the risk ratio of attaining LDA or remission using combination therapy versus monotherapy at induction.The I² and p values for heterogeneity are shown (remission=DAS28<2.6; LDA=DAS28<3.2)
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