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Self-Consistent Proteomic Field Theory of Stochastic Gene Switches

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Figure

FIGURE 1 A schematic representation of the toggle switch. Gene 1 produces proteins of type 1, which repress gene 2; and gene 2 produces proteins of type 2, which repress gene 1.
FIGURE 2 Phase diagram obtained as an exact solution within the SCPF approximation for the single symmetric switch when repressors bind as dimers with X eq ¼ 1 (A), 100 (B), and 1000 (C).
FIGURE 3 Probability that genes are in the active state (A), the mean number of proteins of each type present in the cell Æn(i)æ(B), and the mean number of proteins of each type present in the cell if gene i is in the on-state Æn 1 (i)æ (C) as a function o
FIGURE 4 Evolution of probability distributions for the probability of the gene that will be active (on) after the bifurcation to be on (A) and off (B) and the gene that will be inactive (off) to be on (C) and off (D) as a function of the order parameter X
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