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(1)

In vItro-DIagnostIcs

in the Capital Region Berlin-Brandenburg

(2)

Germany‘s Capital Region Berlin-Brandenburg

Your Partner for Next Generation in vitro-Diagnostics

Berlin-Brandenburg covers the full range of the biotech and pharma value chain, from substance and process development to clinical research, production and services.

In vitro-Diagnostics and bioanalytics in Berlin-Branden-burg means:

» About 20 excellent research institutions focus on the identification of new biomarkers and new platform technologies for diagnostic tools.

» More than 80 small and medium enterprises (SME) as manufacturer or supplier cover a broad spectrum of highly innovative diagnostics. Berlin-Brandenburg develops solutions for next generation in vitro-Diag-nostics and bioanalytics like sensor-actor-molecules and autonomous biosensors, genome-, proteome- and glycan-based multiplex analytics (microarray- and bead technologies) and metabolomics plat-forms for new biomarker strategies.

» Berlin-Brandenburg is the place for implementing clinical validation studies. Germany`s most diversi-fied hospital landscape with the Charité  – Univer-sitätsmedizin Berlin has access to patient cohorts of urban and rural populations of about 180 ethnicities, covering all medical indications. Customers from re-search and industry may have access to advanced biobanking infrastructures.

The Berlin-Brandenburg Center for Molecular Diagnos-tics and BioanalyDiagnos-tics (ZMDB) is the platform for technol-ogy transfer and supports cooperations between sci-ence, clinics and industry. The ZMDB is your interface to get access to Berlin-Brandenburg´s expertise in in vitro-Diagnostics and bioanalytics.

Applied Research Research & Development Clinical Studies Basic Research Product Identification of Biomarkers Genomics/Proteomics/

Glycomics/Metabolomics Validation of BiomarkersMicroarrays · Lab-on-Chip

POCT · Biosensors · Automation

Validation of Biomarkers Biobanking Metabiobanking Production Approval Reimbursement Marketing

(3)

In vitro-Diagnostics in Berlin-Brandenburg

Selected Companies

1 8sens.biognostic GmbH | 2 Alacris Theranostics GmbH | 3 ASTRA BIOTECH GmbH | 4 ATLAS Biolabs GmbH | 5 Attomol GmbH 6 BIOTECON Diagnostics GmbH | 7 BioTeZ Berlin-Buch GmbH | 8 BST Bio Sensor Technology GmbH | 9 caprotec bioanalytics GmbH 10 CellTrend GmbH | 11 Chipron GmbH | 12 CONGEN Biotechnologie GmbH | 13 E.R.D.E.-AAK-Diagnostik GmbH | 14 Epigenomics AG 15 Epiontis GmbH | 16 FILT Lungen- und Thoraxdiagnostik GmbH | 17 GA Generic Assays GmbH | 18 GILUPI GmbH | 19 GlucoMetrix AG 20 Glycotope GmbH | 21 iDoc Institute for Telemedicine and Health Communication GmbH & Co. KG | 22 in.vent DIAGNOSTICA GmbH 23 Institute Cardiac Diagnostics and Therapy (IKDT GmbH) | 24 JPT Peptide Technologies GmbH | 25 Labor Berlin – Charité Vivantes Services GmbH | 26 LGC Genomics GmbH | 27 Limetec Biotechnologies GmbH | 28 Medipan GmbH | 29 Metanomics Health GmbH 30 MicroDiscovery GmbH | 31 Minerva Biolabs GmbH | 32 peptides&elephants GmbH | 33 PolyAn GmbH | 34 Proteome Factory AG 35 Provitro GmbH | 36 SCIENION AG | 37 Seramun Diagnostica GmbH | 38 SIFIN Institut für Immunpräparate und Nährmedien GmbH Berlin | 39 Signature Diagnostics AG | 40 Source BioScience imaGenes GmbH | 41 STRATEC Molecular GmbH | 42 Strix Diagnostics GmbH 43 Surflay Nanotec GmbH | 44 TIB MOLBIOL Syntheselabor GmbH | 45 Zentrum für molekulare Onkologie GmbH

Berlin

Brandenburg

16 1 20 7 40 12 41 13 34 9 35 36 15 4 43 24 14 18 16 21 39 2 19 20 32 6 163 17 11 37 5 20 10 28 23 29 25 44 45 27 26 31 30 42 8 33 38 22
(4)

In vitro-Diagnostics in Berlin-Brandenburg

Research Institutions

1 BAM Federal Institute for Materials Research and Testing | 2 Beuth Hochschule für Technik Berlin – University of Applied Sciences 3 DIfE (German Institute of Human Nutrition) Potsdam Rehbrücke | 4 Charité - Universitätsmedizin Berlin | 5 Deutsches Rheuma-Forschungszentrum Berlin | 6 Fraunhofer Institute for Telecommunications Heinrich Hertz Institute | 7 Fraunhofer Institute for Applied Polymer Research IAP | 8 Fraunhofer Institute for Biomedical Engineering IBMT | 9 Humboldt University of Berlin | 10 IHP GmbH - Innovations for High Performance Microelectronics | 11 Leibniz-Institut für Molekulare Pharmakologie (FMP) | 12 Max Delbrück Center for Molecular Medicine · Berlin-Buch | 13 Max Planck Institute for Infection Biology | 14 Max Planck Institute for Molecular Genetics 15 Max Planck Institute of Colloids and Interfaces | 16 Physikalisch-Technische Bundesanstalt (PTB) | 17 Robert Koch Institute (RKI) 18 Technical University of Applied Sciences Wildau | 19 University of Applied Sciences Lausitz | 20 University of Potsdam

Berlin

Brandenburg

5 9 13 3 7 20 8 10 19 18 14 15 1 16 6 4 11 2 12 17
(5)

Industry

Clini Cal Chemis tr y immuno as sa y m ole Cular Di ag n ost iC s h ema tol og y Co agula ti on m iC robi ol og y Po int of Care tes ting o thers 8sens.biognostic gmbh 1 1 alacris theranostics gmbh 1 aptares ag 1 astra bioteCh gmbh 1 1 1 atlas biolabs gmbh 1 1 attomol gmbh 1 1 1 1 bioteCon Diagnostics gmbh 1 1 bioteZ berlin-buch gmbh 1 1

bst bio sensor technology gmbh 1 1 1

caprotec bioanalytics gmbh 1 Celltrend gmbh 1 1 1 Chipron gmbh 1 Congen biotechnologie gmbh 1 e.r.D.e.-aaK-Diagnostik gmbh 1 1 epigenomics ag 1 epiontis gmbh 1

filt lungen- und thoraxdiagnostik gmbh 1 1 1

ifp institut für Produktqualität gmbh 1 1 1 1

ga generic assays gmbh 1 1

giluPi gmbh 1 1

glucometrix ag 1 1 1

glycotope gmbh 1

iDoc institute for telemedicine and health Communication gmbh & Co. Kg 1 1

in.vent DiagnostiCa gmbh 1 1 1 1 1 1

institute Cardiac Diagnostics and therapy (iKDt gmbh) 1 1

JPt Peptide technologies gmbh 1 1 1 1 1

labor berlin – Charité Vivantes services gmbh 1 1 1 1 1 1 1 1

lgC genomics gmbh 1 1 limetec biotechnologies gmbh 1 1 1 medipan gmbh 1 1 1 metanomics health gmbh 1 microDiscovery gmbh 1 1 1 minerva biolabs gmbh 1 1 1 peptides&elephants gmbh 1 1 1 Polyan gmbh 1 Proteome factory ag 1 1 Provitro gmbh 1 1 sCienion ag 1 1 1 1 1 seramun Diagnostica gmbh 1 1 1

sifin institut für immunpräparate und nährmedien gmbh berlin 1 1 1

signature Diagnostics ag 1 1

source bioscience imagenes 1 1 1

strateC molecular gmbh 1

strix Diagnostics gmbh 1 1

surflay nanotec gmbh 1 1 1

thermo fisher scientific b·r·a·h·m·s gmbh 1 1 1 1 1

tib molbiol syntheselabor gmbh 1 1 1 1 1

Zentrum für molekulare onkologie gmbh 1 1

In vItro-dIagnostIcs In

BerlIn-BrandenBurg

overvIew companIes

(6)

scIence

b as iC r esear Ch iD entifi Ca ti on an D V ali D ati on of b iomar Kers assay De Vel o Pment te Chnol og y De Vel o Pment others

bam federal institute for materials research and testing

1

1

1

Charité – universitätsmedizin berlin

1

1

1

1

Dife (german institute of human nutrition) Potsdam-rehbruecke

1

1

fraunhofer institute for telecommunications heinrich hertz institute

1

fraunhofer institute for applied Polymer research iaP

1

1

fraunhofer institute for biomedical engineering ibmt

1

1

humboldt university of berlin · systems immunology lab

1

1

1

ihP gmbh – innovations for high Performance microelectronics

1

max Delbrück Center for molecular medicine · berlin-buch

1

1

1

max Planck institute for molecular genetics

1

1

1

max Planck institute of Colloids and interfaces

1

1

1

1

1

Physikalisch-technische bundesanstalt (Ptb)

1

1

technical university of applied sciences Wildau

1

1

1

university of applied sciences lausitz

1

1

university of Potsdam

1

1

1

1

In vItro-dIagnostIcs In BerlIn-BrandenBurg overvIew researcH InstItutIons

(7)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

8sens.BIognostIc gmBH

Key fIgures

1 foundation: 2000 1 employees: 10

8sens.biognostic gmbh design, develop and produce in vitro-diagnostica (iVD) up to Ce approval.

We offer: custom-made development and production of immunochromatographic lateral flow tests and microti-terplate-based assays (elisas, etc.) as well as production of antibody conjugates (colloidal gold, latex, dyes etc.) for research and production. our key business activities also cover novel protein-based macro arrays for multiana-lyte detection (e. g. panels for heart attack, heart risk and torCh) as well as adaptable reader systems for easy quan-tification of rapid test and macro array results.

marKet segments

1 lateral flow assays

1 reader systems for quantification 1 Development on demand

1iVD-orientated nanotechnology

products 1 tecHnologIes

1 rapid tests

1 Quicksens® h-fabP, ctni 1 Quicksens® CrP, hs-CrP

1 reader system Quicksens® Ω100

contact 8sens.biognostic gmbh robert-rössle-straße 10 13125 berlin · germany www.biognostic.de Volker landorff landorff@biognostic.de

(8)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

alacrIs tHeranostIcs gmBH

Key fIgures

1 foundation: 2008 1 employees: 15

the company is based on novel translational medicine/ systems biology technology developed at the max Planck institute for molecular genetics in berlin coupled with pref-erential access to the world’s most cost effective sequenc-ing and genotypsequenc-ing technology.

the scientific founders are among the world’s foremost ex-perts in sequencing technology, systems biology and bio-medicine.

alacris theranostics offers its services internationally in europe and north america.

products 1 tecHnologIes

1 Cutting-edge next generation sequencing technology 1 genome, epigenome, and transcriptome sequencing 1 Proprietary technology platform modCell™

1identification of diagnostic markers

1in silico simulations for the study and evaluation of

signal pathways relevant for cancer

1 simulation of drug effects

1 stratification of cancer patients for their clinical trials

and for biomarker discovery

major r&d-topIcs

1 biomarker discovery

1 Computer modeling for cancer drug validation 1 non-invasive cancer genome sequencing

1 Partner in the it future of medicine-project within

the fet flagship initiative - Partner in the oncotrack-project within the innovative medicine initiative

contact alacris theranostics gmbh fabeckstraße 60-62 14195 berlin · germany info@alacris.de www.alacris.de Dr. bodo lange

(9)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

aptares ag

Key fIgures

1 foundation: 2002 1 employees: 18

aptares is a leading biotechnology company providing oli-gonucleotide aptamers as an alternative to common anti-bodies. aptares is the sole owner of the proprietary mono-lex procedure for aptamer selection and its applications. We offer high resolution bioanalytics and the technology for downstream processing for immunoglobulins using an innovative igg fc-specific binder (like protein a). a qual-ity management system ensures transparent, validated and reproducible processes. the bioanalytical service includes high resolution 2D-gel electrophoresis, mass spectrometry, n-terminal sequencing, functional tests and more. the protocols are custom tailored to validate product identity, quantitate side products, and validate processes as well as binding specificities of antibodies and aptamers.

marKet segments

1  aptamer selection and applications 1  bioanalytics

products 1 tecHnologIes

1  aptamers

1  antibody Purification

1  Protein identification / Proteomics

1  n-terminal sequencing (edman- sequencing) 1  2D high resolution electrophoresis

1  malDi-tof-ms analytic 1  structure Validation

1  host Cell Protein analysis (hCP-analysis)

major r&d-topIcs

1  new aptamer based active agents 1  new aptamer based applications

contact aptares ag tempelhofer Weg 11-12 10829 berlin · germany Phone +49 30 24537613 fax +49 30 24537622 info@aptares.de www.aptares.de

(10)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

astra BIotecH gmBH

Key fIgures

1 foundation: 2009

astra biotech gmbh is a quality-focused company with its success founded on dependable science and strong rela-tionships to develop iVD-compliant, Ce-labelled in vitro- diagnostic assays for laboratories specialising in multi-medical fields or in education. the product range available includes reagents for detecting and calibrating human hor-mones, genetic diseases, tumour markers, allergens, anti-bodies, and recombinant proteins.

marKet segments 1iVD 1 molecular diagnostics 1immunoassays products 1 tecHnologIes elisa, PCr, miCroarray-on-a-ChiP

1 hormonal diagnostics, metabolism, fertility,

pre- and neonatal

1tumourmarker 1anaemia (ferritin)

1allergy (ige- total and specific),

1 osteoporosis, thrombosis, sensitivity towards

anticoagulants, sensitivity to antidepressants

1torCh, hiV, niche diseases

1 Conjugates, calibrators, recombinant proteins,

antigens, allergens

major r&d-topIcs

1 research on brain stroke, heart attack treatment and

bone fracture repair

1 stem cells in treatment of different diseases

contact astra bioteCh gmbh im biotechnologiepark · tgZ i 14943 luckenwalde · germany Phone +49 3371 681 450 fax +49 3371 681 451 info@astrabiotech.de www.astrabiotech.de anna fot (business manager)

alexandra ghica-Cantacuzino (international sales and marketing)

(11)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

atlas BIolaBs gmBH

Key fIgures

1 foundation: 2006 1 employees: 12

atlas biolabs gmbh is a leading provider of complex analyses in molecular genetics including microarray-based genomic services, targeted sequence capture, and next generation sequencing.

marKet segments atlas biolabs performs

1 genome-wide gene expression and snP analyses 1array Cgh

1 Comprehensive mutation profiling and other novel

ngs applications

for academic institutions, pharmaceutical and biotechno-logical enterprises, as well as for clinicians and registered doctors.

products 1 tecHnologIes

the following services are provided by atlas biolabs:

1 exome enrichment

1 next generation sequencing 1 genotyping

1 expression profiling

1 Whole genome human snP genotyping 1 molecular karyotyping

1targeted sequence enrichment 1 raindance sequence enrichment 1 sample preparation

1 bioinformatics analysis and project management 1 methylation 1 oncocarta contact atlas biolabs gmbh friedrichstraße 147 10117 berlin · germany Phone +49 30 3198966 0 fax +49 30 3198966 19 customer-support@atlas-biolabs.com www.atlas-biolabs.com

Prof. Dr. Peter nürnberg (Ceo)

(12)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

attomol gmBH

Key fIgures

1 foundation: 1997 1 employees: 12

Development, production and distribution of iVD-marked diagnostic tests under attomol brand or oem

1 main technologies are protected by 5 patents 1 Direct marketing in germany

1 formation of an international distributor network is not

yet finished

1 Co-founder of the research community bioresponse e.V.:

www.bioresponse.de

marKet segments

1 molecular genetics

1 molecular diagnostics of pathogens 1autoimmunodiagnostics

products 1 tecHnologIes

looptag real time PCr or Dna-lina strip tests: mycobacteria, bordetella, borrelia, mycoplasma

1 Quicktype mutation assays: thrombophilia, drug

metabolism, lactose intolerance etc.

1 bead assay: 11plex anti-nuclear-antibody confirmation 1antibody lina strip tests: anti-gangliosides,

anti-phospholipids

major r&d-topIcs

1technologies:

real time PCr, multiplex technologies, bead assay

1applications:

anti-lipid antibody detection, coagulation risk profiling

contact attomol gmbh schulweg 6 · ot lipten 03205 bronkow · germany www.attomol.de Dr. Werner lehmann

(13)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

BIotecon dIagnostIcs gmBH

Key fIgures

bioteCon Diagnostics was founded in 1998 and currently has 51 employees. our expertise is microbiological service testing of food, beverage and pharmaceutical products. our company focuses on the development of rapid and in-novative detection systems for pathogenic, spoilage and genetically modified organisms based on real time PCr. besides detection kits, the foodproof product line also in-cludes kits for sample preparation.

today, as an international biotechnology company, bioteCon Diagnostics develops, produces and markets these prod-ucts. We foster a growing network of distributors as well as offer contract development and production to other bio-tech companies.

Due to strong partnerships with food, beverage and pharma-ceutical companies, bioteCon Diagnostics is well aware of their current and future problems. our experience lends to our strong capability to find new and economically interesting approaches to these existing and upcoming problems both in production and processing. as a small company, we maintain our flexibility to respond to indus-try concerns quickly and efficiently. simply put, we provide desired solutions. contact bioteCon Diagnostics gmbh hermannswerder 17 14473 Potsdam · germany Phone +49 331 2300 00 fax +49 331 2300 299 bcd@bc-diagnostics.com www.bc-diagnostics.com

Kornelia berghof-Jäger, Ph. D. (Ceo) alois schneiderbauer (Cbo)

© fotol ia · sv en h oppe

(14)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

BIoteZ BerlIn-BucH gmBH

Key fIgures

1 foundation: 1992 1 employees: 20

We understand ourselves as partners of biotechnological research, pharmaceutical industry and lab analysis for in-novation and quality. our business Portfolio:

1in vitro-diagnostics: e. g. for therapeutical antibodies

(tab) to measure the interaction between tab and antigens to optimize the treatment

1 Customized synthesis of oligonucleotides

(high level services)

1 support of mycotoxine and vitamin analysis; production

of very effective immunoaffinity columns, elisas, and toxin and detection conjugates

1 elisa development, conjugation and labeling of

biomolecules, other services

1 signal/assay enhancement using our high-tech molecule

(Polystrept r), e. g. for lateral flow tests

marKet segments

1iVD development and production 1 oligonucleotid synthesis 1immobilization of molecules 1 elisa development

1 feed and food analysis

products 1 tecHnologIes

outstanding expertise in immunoassays. own patents and iP:

1 signal enhancement by Polystrept r (highest

immo bilization, outstanding biotin binding capacities)

1 Coating of surfaces for binding biotinylated molecules 1 unique iVD technology for measuring therapeutic

antibodies and antigen in patient serum

1immobilisation of biomolecules, e. g. on surfaces and

columns

major r&d-topIcs

1 iVD development for the therapeutic antibodies:

enbrel, avastin, herceptin

1aptamere development contact bioteZ berlin-buch gmbh haus 79 · robert-rössle-straße 10 13125 berlin · germany Phone +49 30 94892130 fax +49 30 9494509 info@biotez.de www.biotez.de

(15)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

tHermo fIsHer scIentIfIc, B·r·a·H·m·s gmBH

Key fIgures

thermo scientific b·r·a·h·m·s biomarkers investigate, de-velop and manufacture novel diagnostic testing procedures to improve early diagnosis and treatment of life threatening diseases. With our high-quality immunodiagnostic tests for sepsis, cardiovascular, pulmonary, and cancer disorders as well as prenatal screening we contribute to the creation of a healthier future – to the greatest advantage for medical professionals and patients.

in future simple and economic blood tests will be of great importance for an early detection and successful treatment of diseases. With our Know-how and technologies we are confident to play an active role in this future: our products provide important information to clinicians and laborato-ries in more than 65 countlaborato-ries worldwide and support their clinically and economically relevant decisions.

on the basis of our completely owned patents and with help of more than 470 employees worldwide thermo sci-entific b·r·a·h·m·s biomarkers are leading in specific mar-ket places and therapeutic areas.

products 1 tecHnologIes

1 fully automated KryPtor® platform with traCe®

technology (traCe = time-resolved amplified Cryptate emission)

1 radioimmunoassay 1 lumineszenzassay 1 enzymimmunoassay

major r&d-topIcs

the aim of our basic research is to identify new biomarkers, with support by international cooperations and reputable research institution.

contact

thermo fisher scientific b·r·a·h·m·s gmbh neuendorfstraße 25 16761 hennigsdorf · germany Phone +49 3302 8830 fax +49 3302 883100 info.brahms@thermofisher.com www.thermoscientific.com/brahms

(16)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

Bst BIo sensor tecHnology gmBH

Key fIgures

1 foundation: 1991 1 employees: approx. 20

bst’s history dates back to 1975 when a biosensor re-search group started at the berlin academy of sciences. already in 1982 the first european glucose analyzer based on a multi-way glucose biosensor could be launched suc-cessfully.

today, bst is market leader in multi-way biosensors in europe and an international operating company in e. g. asia, eastern and Western europe.

bst’s core competence is the development and production of multi-way biosensors as well as instruments based on these multi-way biosensors for laboratory and PoCt appli-cations. in addition to that also all related consumables are developed, produced and marketed by bst.

marKet segments

1 PoCt diagnosis of glucose and other metabolites based

on multi-way biosensors

1 Determination of glucose and other metabolites for

clinical chemistry

1 Diagnosis of training state of athletes (lactate analysis)

products 1 tecHnologIes

1immobilising of biological recognition elements for

usage in diagnostic tools

1 Conception, development and production of: 1 multi-way biosensors for pmol/l to mmol/l

concentrations

1instruments based on multi-way biosensors

(e. g. gluKometerPro, laCPro, labtrend)

1all related consumables for the application of

multi-way biosensors

major r&d-topIcs

1 Development of potentiometric sensors based on

thick film technology

1 Development of minimal invasive glucose system

contact

bst bio sensor technology gmbh buchholzer straße 55 – 61 13156 berlin · germany Phone +49 30 7676731 0 fax +49 30 7676731 28 info@bst-biosensor.com www.bst-biosensor.com

(17)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

caprotec BIoanalytIcs gmBH

Key fIgures

1 foundation: 2006, start of building up operation

in 2008

1 employees: 30

caprotec bioanalytics gmbh has developed a ground-break-ing, proprietary technology to reduce the complexity of protein mixtures and samples in a targeted and directed manner.

1 caprotec’s Capture Compound mass spectrometry

(CCms) technology is based on trifunctional Capture Compounds™ which enable capturing and isolating proteins based on their functionality

1 CCms is closing a technology gap between shotgun

approaches and pull-down experiments – thus

addressing an unmet need in the proteomics community

1the company is commercializing the CCms technology

as kits for research applications and customized Capture Compounds in collaborations with pharmaceutical companies or academic research

1the focus is on investigating mechanisms of drug action

and avoidance of toxicological effects of small molecule drugs

marKet segments

1 Drug discovery 1 Proteomics research

products 1 tecHnologIes

Capture Compound mass spectrometry (CCms)

1 caproKits™ 1 caprobox™ 1 capromag™ 1impromed

major r&d-topIcs

1 small molecule – protein interactions 1 Proteomics 1 signal transduction 1 Protein kinases contact caprotec bioanalytics gmbh Volmerstraße 5 12489 berlin · germany www.caprotec.com Prof. Dr. hubert Köster

(18)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

celltrend gmBH

Key fIgures

1 foundation: 1998 1 employees: 8

Celltrend is a certified biotech and diagnostic company. We are offering services and products:

1 bioassays for drug research and development 1 Cell culture testing

1immunogenicity testing

1 Development and production of immunoassays

marKet segments 1 Pharma/biotech/Cosmetics 1 Contract research 1 Contract analysis 1 Contract production 1 Diagnostics products 1 tecHnologIes

1 mammalian cell culture

1immunoassays for research and diagnostic

major r&d-topIcs 1 oncology 1 Cardiovascular diseases 1 Detection of autoantibodies 1 biomarker development contact Celltrend gmbh im biotechnologiepark · tgZ 2 14943 luckenwalde · germany Phone +49 3371 681 290 fax +49 3371 681 312 info@celltrend.de www.celltrend.de

(19)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

cHIpron gmBH

Key fIgures

1 foundation: 2004 1 empoyees: <15

Chipron gmbh develops and manufactures Dna macro-arrays on polymer supports. the company specializes in assay development for pathogen detection, mutation analysis and food analysis based on its proprietary lCD-array platform.

lCD-array Kits for hPV typing, kras mutation analysis, de-tection of fungal or bacterial pathogens and meat species identification are distributed in over 15 countries through a network of distribution partners.

apart from catalogue products Chipron offers customized lCD-array Kits for particular demands and has developed over 100 of such assays during the last 5 years for in-dustrial and governmental customers. lCD-array Kits are available as ruo or Ce-iVD kits and as oem products on demand.

the minimal requirements for specific lab instrumentation in combination with the simple but comprehensive data readout by the slidereader software make lCD-arrays a very robust and economical solution for virtually any labo-ratory with experience in PCr.

marKet segments

Dna-based detection assays for human or veterinary pathogens, mutation analysis and food analysis

products 1 tecHnologIes

1 PCr-based Dna macroarray kits for pathogen, species

and mutation detection

1 non fluorescent data readout by transmission light

scanning and slidereader software

1 scanner, centrifuge and analysis software

major r&d-topIcs

1 Dna/PCr-based quick tests

contact Chipron gmbh eresburgstraße 22 – 23 12103 berlin · germany Phone +49 30 78799470 fax +49 30 78799499 info@chipron.com www.chipron.com Dr. Volker heiser heiser@chipron.com

(20)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

congen BIotecHnologIe gmBH

Key fIgures

1 foundation: 1998 1 employees: > 25

Congen is specialized in food testing by molecular analy-sis based on Dna and rna detection. Congen has been a pioneer for over a decade in the development and applica-tion of food and feed analysis by real time PCr. Due to our experience in this field, we have a worldwide unmatched competence. We are offering a complete package consist-ing of:

1 Providing fully accredited service

1 full range of real time PCr kits for every real time

PCr cycler

1 full range of kits and protocols for sample preparation 1 real time PCr core reagents (suremaster and

sureCyle®)

1 real time PCr training and full support for real time PCr

laboratory

our mission is to serve the food industry with an excellent service and with standardized and reliable test kits in order to realize highest possible food safety and food quality.

products 1 tecHnologIes

the full spectrum of our analytical services and products is integrated in our program called:

surefood®

the surefood program covers parameters in the applica-tion of gmo, allergen, pathogen, animal, plant detecapplica-tion. in all the above application fields Congen is an interna-tionally highly recognized and accepted partner for service and real time PCr reagents. the quality of the analyses is assured by using validated methods. Congen is accredited according to the en iso 17025:2005. all kits are manufac-tured according to the iso 9001:2008.

contact Congen biotechnologie gmbh robert-roessle-straße 10 13125 berlin · germany Phone +49 30 948935 00 fax +49 30 948935 10 info@congen.de www.congen.de

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Industry

CliniCal Chemistry

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immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

e.r.d.e.-aaK-dIagnostIK gmBH

Key fIgures

1 foundation: 2005

e.r.D.e.-aaK-Diagnostik gmbh is a diagnostics laboratory that offers the detection of diverse autoantibodies (agaab) in sera.

agonistic autoantibodies (agaab) are directed against cellu lar receptors, particularly those involved in heart func-tion, blood pressure regulation and vascular diseases. agaab are frequently detected in patients with:

1 DCm, myocarditis:

agaab against β1-adrenergic receptor and m2-muscerinergic receptor

1 hypertension:

agaab against α1-adrenergic receptor

1 Diabetes type 2:

agaab against α1- and at1-adrenergic receptor

1 Dementia:

agaab against α1- and β2-adrenergic receptor

to determine the agaab-status different special analysis techniques are used. the prevalence of the different agaab in the different diseases varies from 30 to 90 %.

Patients will benefit – at a given agaab indication – from a personalized, specific medicamentous therapy, which ac-counts for the agaab induced malfunction of receptors.

products 1 tecHnologIes

the detection of the agonistic autoantibodies (agaab) is realized by the following analysis techniques:

1 elisa (not functional):

Detection of a single agaab

1 bioassay (functional):

analysis of all agaab of the sample

1 CalCium (functional):

measurement of intracellular calcium transients

contact

e.r.D.e.-aaK-Diagnostik gmbh

biomedizinischer forschungscampus berlin-buch robert-roessle-straße 10 13125 berlin · germany Phone +49 30 9489 2226 fax +49 30 9489 2229 mobile +49 1607537115 bimmler@aak-diagnostik.de www.aak-diagnostik.de mrs. Dipl.-ing. marion bimmler

(22)

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1

epIgenomIcs ag

Key fIgures

1 foundation: 1998 1 employees: 82

epigenomics is a molecular diagnostics company develop-ing and commercializdevelop-ing a pipeline of proprietary products for cancer.

the Company’s products enable doctors to diagnose cancer earlier and more accurately, leading to improved outcomes for patients.

epigenomics’ lead product, epi proColon, is a blood-based test for the early detection of colorectal cancer, which is currently marketed in europe and is in development for the us.

the Company’s technology and products have been vali-dated through multiple partnerships with leading global diagnostic companies including abbott, Qiagen, sysmex, and Quest Diagnostics.

epigenomics is an international company with operations in europe and the us.

products 1 tecHnologIes

1 epi proColon (marketed in eu; in r&D for us) 1 epi prolung (marketed in eu)

1 Pipeline with further products for colorectal, lung

and prostate cancer

1applications in early detection, diagnosis, prognosis,

and drug response prediction

1all products based on proprietary Dna methylation

technology

major r&d-topIcs

1 biomarker discovery and validation

1 iVD development for eu and us (iso 13485) 1 Companion diagnostics r&D for pharma partners 1 Dna methylation technologies

contact epigenomics ag Kleine Präsidentenstraße 1 10178 berlin · germany Phone +49 30 24345 0 fax +49 30 24345 555 contact@epigenomics.com www.epigenomics.com

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Industry

CliniCal Chemistry

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immunoassay

1

moleCular DiagnostiCs

1

hematology

1

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1

miCrobiology

1

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others

1

epIontIs gmBH

Key fIgures

1 foundation: 2003 1 employees: 11

using a novel molecular diagnostics technology, epiontis offers an immune cell monitoring service as well as cus-tomized development of epigenetic assays.

marKet segments

1 Quality control for cell therapies 1immunomonitoring

1 epigenetic markers 1 biomarkers

products 1 tecHnologIes

1immunomonitoring service (fee for service)

based on epigenetic markers for immune cells

1assays for cell therapy quality control

(contract development)

major r&d-topIcs

1 Discovery of novel epigenetic markers 1 markers specific for particular cell types

1 future diagnostic (prognostic, predictive, monitoring)

markers contact epiontis gmbh rudower Chaussee 29 12489 berlin · germany Phone: +49 30 6392 3474 hoffmueller@epiontis.com www.epiontis.com

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Industry

CliniCal Chemistry

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immunoassay

1

moleCular DiagnostiCs

1

hematology

1

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1

miCrobiology

1

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1

others

1

fIlt lungen- und tHoraxdIagnostIK gmBH

Key fIgures

1 foundation: 1992 1 employees: 7

filt – lung- and thorax Diagnostic gmbh – is developer and manufacturer of products with focus on ‘exhaled breath analysis’ and airways inflammation diagnostic for treat-ment managetreat-ment in asthma and CoPD.

our mission in filt is to use the combined experiences in medical functional and laboratory diagnostic to generate innovative products to improve the early diagnostic of in-flammatory diseases and its therapeutic management.

marKet segments

1 Pulmonology 1asthma 1 CoPD

1 PoCD of inflammatory diseases

products 1 tecHnologIes

1 eCoscreen 2 (ebC Collector f) 1 eCoCheck (ebC analyser for h

2o2, ph, lactat)

major r&d-topIcs

lung function diagnostic, specialized in fractionated breath collection and measurement of flows, volumes, pressures, gases and biomarkers for analytical evaluation of inflam-matory diseases

contact

filt lungen- und thoraxdiagnostik gmbh robert-rössle-straße 10 13125 berlin · germany Phone +49 30 94892114 fax +49 30 94892115 info@filt.de www.filt.de

(25)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

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1

miCrobiology

1

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1

others

1

ga generIc assays gmBH

Key fIgures

1 Developing, manufacturing and distributing in vitro-

diagnostic assays in the field of systemic autoimmunity like rheumatic diseases, autoimmune hepatitis, autoimmune neuropathies, vasculitis, autoimmune kidney diseases, gastroenterology and anti-phospholipid syndrome (aPs)

1 market leader for anti-asialoglycoprotein receptor elisa

(anti-asgPr) (autoimmune hepatitis)

1inventor and market leader for aPs antibody profiling by

immunodot

1inventor and market leader for anti-glycoprotein 2

elisa (gP2) a new serological marker for Crohn’s disease

1 manufacturing cell-based immunofluorescence assays

like hep2 cells, anCa and Crithidia luciliae cells

1 operating worldwide

marKet segments

1in vitro-diagnostics

products 1 tecHnologIes

1ifa (hep2 cells, anCa, Crithidia luciliae cells

and tissue sections)

1 elisa 1immunodot 1 rapid tests 1 latex tests

major r&d-topIcs

1 new diagnostic markers for autoimmune neuropathies 1 new diagnostic marker for gastroenterology

contact ga generic assays gmbh ludwig-erhard-ring 3 15827 Dahlewitz/berlin · germany Phone +49 33708 9286 0 fax +49 33708 9286 50 info@genericassays.com www.genericassays.com

(26)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

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1

others

1

gIlupI gmBH

Key fIgures

1 foundation: 2006 1 employees: 18

1 several collaborations with various national

and international medical universities

1international company with operations in europe

and the us

1 several positive ethical votes for clinical trials 1 Proof of concept in vivo

1awarded for a grant “medizintechnik –

innovationswettbewerb 2007” of the bmbf

marKet segments

the inventions of the giluPi gmbh are in the market area of molecular diagnostics. in the prenatal sector the market for screening for trisomy 21 is about 2,5 billion euro. in the field of cancer for isolating rare tumorcells the market is about 1 billion euro.

products 1 tecHnologIes

giluPi gmbh is developing, marketing, and selling innova-tive new nanotechnology-based medical devices to detect and monitor circulating rare blood cells, with a strong focus on the prenatal diagnostic and cancer diagnostic market

1 one application of the new nanodetector device is

in the area of prenatal diagnosis, e. g. for analysis of chromosomal aberrations such as that found in Down syndrome

1another application is focusing on detecting and

enriching rare circulating tumor cells (CtC) from the peripheral blood of cancer patients as markers of disease recurrence and efficacy of systemic cancer treatment

major r&d-topIcs

1 Development of the functionalized structured medical

wire (fsmW)

1 biomarker discovery and validation 1 Development of antibodies contact giluPi gmbh am mühlenberg 11 14476 Potsdam · germany Phone +49 331 58184782 www.gilupi.de inga Kliem inga.kliem@gilupi.com

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Industry

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1

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1

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1

glucometrIx ag

Key fIgures

1 glucometrix ag

was founded in 2001. it has 3 major subsidiaries that concentrate on different aspects of enhancing the quality of life for people suffering from diabetes.

1 glucometrix nib gmbh

develops medical devices for measuring blood sugar non-invasively, i. e. without puncturing the skin.

1 glucometrix PVs gmbh

develops a new production method for insulin which promises a purer insulin with less side effects.

1 glucometrix Pharma VV gmbh

develops, manufactures and markets medicinal products related to wound healing. these are particularly suited for diabetic wounds.

products 1 tecHnologIes

1 Development of expression platforms for

biomedical products

1 Development of downstream purification methods 1 biosept line of wound treatment products

major r&d-topIcs

1 opto-acoustical device to measure blood sugar

non-invasively (in collaboration with eth Zurich)

1 immunological assay to determine glycated serum

proteins (PoC-assay; in collaboration with fhi bmt)

1 genetic predisposition for diabetes mellitus

1 Cost-effective production methods for human insulin

contact glucometrix ag am mühlenberg 11 14476 Potsdam · germany info@glucometrix.de www.glucometrix.de P.P. schikora (Ceo)

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Industry

CliniCal Chemistry

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immunoassay

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moleCular DiagnostiCs

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1

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miCrobiology

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others

1

glycotope gmBH

Key fIgures

1 foundation: 2001 1 employees: 75

glyCotoPe is a leading biopharmaceutical company in the fields of glycomics and immunotherapeutics and one of the rare full service providers in the development of biologics. for proprietary and customers’ drug development pro-grams glycotope has established a business unit to per-form immunomonitoring of clinical samples. offered also as a stand-alone service to support clinical studies, the pharmacokinetic and – dynamic characteristics of biother-apeutics and the immune status of patients are determined according to the gClP guidelines.

a variety of kits for quantitative characterization of the cellular immune status and responses is provided by gly-cotope-biotechnology. the kits are used by lab physicians, clinical research organisations and pharmaceutical r&D departments to better understand the activity of a number of immune cells that are relevant in a variety of diseases www.glycotope-bt.com.

products 1 tecHnologIes

1 Design and conduct of immunomonitoring assays to

support clinical development

1 Diagnostic test kits based on flow cytometry procedures

to measure various cell functions for functional characterisation of cellular immune response, t-cell analysis and characterisation of haematological relevant autoimmune diseases

major r&d-topIcs

1 Continuous development of project specific

immunomonitoring assays contact glycotope gmbh robert-roessle-straße 10 13125 berlin · germany Phone +49 30 9489 2600 fax +49 30 9489 2609 info@glycotope.com www.glycotope.com

Dr. hans baumeister (associate Director Clinical immunomonitoring)

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Industry

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immunoassay

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moleCular DiagnostiCs

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hematology

1

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miCrobiology

1

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others

1

Idoc InstItute for telemedIcIne and HealtH communIcatIon gmBH & co. Kg

Key fIgures

1 founded 2004

iDoc provides innovative solutions within the fields of tele-medicine. the institute combines medical expertise with professional it and communication management.

marKet segments 1 telemedicine 1 telesomnology 1 telemonitoring 1 healthcare networks 1 Dementia care products 1 tecHnologIes

1telemedical screening for sleep apnea 1 telemedical monitoring for diabetes,

metabolic syndrom

1 telemedical data exchange application 1 telemedical network for multicenter studies 1 telemedical care support for dementia

major r&d-topIcs

1 telemedicine 1 Prevention

1 Comprehensive medical services

contact

iDoc institute for telemedicine and health Communication gmbh & Co. Kg Posthofstraße 8

14467 Potsdam · germany www.idoc.de

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Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

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1

others

1

Ifp InstItut für produKtqualItät gmBH

Key fIgures

1 founded 2004 1 employees: 100

ifp institut für Produktqualität gmbh is an independent competence centre for food, feed and pharmaceutical ana-lytics, offering a complete range of services and diagnostic products. the combination of expert staff, state-of-the-art laboratory equipment and food diagnostics specifically developed and produced by ifp guarantees high-quality analyses and competent service. several of ifp’s innovative product lines are being successfully distributed worldwide by renowned cooperation partners.

products 1 tecHnologIes

1 microbiological test kits for the microtiter plate based

determination of all water-soluble vitamins in food, pharmaceuticals and human serum

1 real-time PCr kits for the detection of food pathogens,

gmo, allergens, plant and animal species

1immunological assays for the rapid on-site detection

and quantitative determination of food allergens

1 microtiter plate based enzymatic test kits for the

photometric determination of sugars, organic acids and other metabolites in food

major r&d-topIcs

1 Development of improved bioanalytical methods for

food testing purposes

11 strong involvement in funded research projects

contact

ifp institut für Produktqualität gmbh teltowkanalstraße 2 12247 berlin · germany Phone +49 30 7668600 fax +49 30 76686050 info@produktqualitaet.com www.produktqualitaet.com

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Industry

CliniCal Chemistry

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immunoassay

1

moleCular DiagnostiCs

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hematology

1

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1

miCrobiology

1

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1

others

1

In.vent dIagnostIca gmBH

Key fIgures

your service Provider for human Diagnostics

1 biomaterials of human origin 1 enhanced biobanking 1 Protein chemistry

1 Contract-based development of proteins and

diagnostic tests

1 Clinical studies and Ce marking procedures for iVD

marKet segments in.vent supplies you with

1 Clinically defined sera and plasma with a worldwide

unique variety of matrices

1 Clinically defined human biomaterials like

synovial fluid, Csf, etc.

1 stool, faecal samples 1Various tissues

1a great variety of proteins

1 services in development and manufacturing

of diagnostic tests

products 1 tecHnologIes

1 in.vent’s procurement of human biomaterial is always

strictly oriented towards individual projects as well as highest ethical standards and superior quality. all materials are procured exactly with the information you need and on your specific demand.

1 in.vent’s enhanced biobanking serves you with clinically

characterized human biomaterials that match exactly your needs to build your customized biobank.

1 in.vent’s newest products are the execution of the

laboratory part of clinical studies and of Ce marking procedures.

We would be delighted finding solutions that fit you.

major r&d-topIcs

in.vent meets your individual requirements for the complete value chain which involves the areas of r&D, production and quality control with a strictly emphasis on reliability, quality and adherence to schedules.

contact in.vent DiagnostiCa gmbh neuendorfstraße 17 16761 hennigsdorf · germany Phone +49 3302 55199 11 www.inventdiagnostica.de

Dr. J.-m. hollidt (managing Director) jm.hollidt@inventdiagnostica.de

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Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

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hematology

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1

others

1

InstItute cardIac dIagnostIcs and tHerapy (IKdt gmBH)

Key fIgures

1 foundation: 2002 1 employees: 8

iKDt is a leading laboratory worldwide in differential diag-nostics of viral infections and inflammation of heart muscle tissue following the international recommendations. three main topics will be covered for routine diagnostics:

1 histology

1immunohistochemistry and 1 molecular virology

iKDt is the only cardiological laboratory performing mole-cular diagnostics of endomyocardial biopsies in germany which is accredited by College of american Pathologists (CaP) according to fDa guidelines. Customers for our biop-sy diagnostics are hospital-affiliated institutions or private doctor offices.

by its platform innovative Diagnostics iKDt lab as one of the first service providers in europe offers for customers the prompt access to two innovative research technolo-gies – and taqman low-Density-arrays (applied biosys-tems) for gene expression studies or microrna profiling, and bead-based luminex technology for multiplex mea-surement of cytokine and immunological profiles.

marKet segments

1 molecular diagnostics and research in cardiology

products 1 tecHnologIes

services provided:

1 routine differential diagnostics of endomyocardial

biopsies on cardiomyopathies

1 molecular diagnostic service

major r&d-topIcs

1 microrna profiling in myocardial tissue and

peripheral blood

1 gene expression studies in cardiac patients 1autoantibodies in cardiac patients

1 mutation screening in patients with cardiomyopathy

contact

institute Cardiac Diagnostics and therapy (iKDt gmbh) moltkestraße 31

12203 berlin · germany info@ikdt.com

www.ikdt.com

www.innovative-diagnostics.eu Dirk lassner, PhD (managing Director)

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Industry

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1

immunoassay

1

moleCular DiagnostiCs

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1

Coagulation

1

miCrobiology

1

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1

others

1

jpt peptIde tecHnologIes gmBH

Key fIgures

1 foundation: 2004 1 employees: 45

1 offices: berlin, boston, brussels

1 Collaborations: nih, Duke university, harvard medical

school (usa), Karolinska institutes (sweden), biontech ag (germany)

JPt Peptide technologies (JPt) is an iso 9001:2008 cer-tified and gClP audited global supplier and development partner for innovative peptide related immune monitoring tools, molecular diagnostics and biomarkers. JPt has de-veloped several high-content peptide technologies that allow proteome spanning and multiplexed discovery, vali-dation, quantification of biomarkers as well as monitoring humoral and cellular immune responses in disease pro-gression and under therapeutic invention.

marKet segments

1 molecular and immune diagnostics 1 biomarker discovery and validation 1Vaccine and immunotherapy development

products 1 tecHnologIes

1 Pepstartm

Peptide microarray platform for seromarker discovery and immune monitoring

1 Pepspottm

ultra high-throughput peptide synthesis approach for proteome wide t-cell epitope discovery

1 Pepmixtm

Peptide pool platform for profiling cellular immune responses

1 spiketidestm

small scale peptide technique for biomarker quantification

major r&d-topIcs

1 seromarker discovery, validation and quantification 1 Development of diagnostic tools for immune monitoring

and patient stratification

1 Peptide discovery, qualification and optimization

contact JPt Peptide technologies gmbh Volmerstraße 5 12489 berlin · germany Phone +49 30 6392 5500 fax +49 30 6392 5501 info@jpt.com www.jpt.com

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Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

laBor BerlIn – cHarIté vIvantes servIces gmBH

Key fIgures

1 foundation: 2011

the company is the service subsidiary of europe’s largest hospital laboratory for clinical pathology and offers com-plete solutions for any kind of testing for the ivd industry, Cros, the pharmaceutical industry, life science companies and research facilities.

labor berlin performs > 20 mio analyses in clinical pa-thology per year; it is the exclusive laboratory partner of Charité universitätsmedizin berlin and the Vivantes net-work for health and provides the diagnostics for approxi-mately 9.000 in-house patients a day and over 800.000 out-patients per year.

products 1 tecHnologIes

1Very broad portfolio of routine diagnostic testing 1individual patient services (health monitoring) 1testing of new preclinical diagnostics systems

(prototypes)

1 high throughput testing under routine conditions of

novel diagnostic platforms

1 Co-development of new biomarkers with industrial

partners

1Validation of new bioassays for ivd industry

1 Design, realization and analysis of clinical studies for

Cros, pharmaceutical industry, life science companies and research facilities

1 field tests of telemedical it solutions

major r&d-topIcs

1 Co-developing and establishing a fully automated

platform for microbiological pathology

1 Data collection on preanalytical systems 1 Co-developing and establishing a routine

tele-haematological it solution for linking 12 hospitals in berlin

contact

labor berlin – Charité Vivantes services gmbh augustenburger Platz 1 13353 berlin · germany www.laborberlin.com Dr. andreas Weimann andreas.weimann@laborberlin.com florian Kainzinger florian.kainzinger@laborberlin.com

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Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

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1

others

1

lgc genomIcs gmBH

Key fIgures

1 foundation: 1993 as agoWa 1 lgC group acquires agoWa in 2005

1 rebranded and established in april 2010 as lgC

genomics

1 number of employees: 50

a division of the lgC group, lgC genomics delivers high quality services and products for Dna and genetic analysis and sample preparation including:

1 next generation sequencing

1 Dna sequencing and library construction 1 nucleic acid extraction services

1 Dna extraction products

1 pharmacogenetics and diagnostic services.

lgC is an international science-based company and market leader in analytical, forensic and diagnostic services and reference standards.

marKet segments

1 Pharmaceutical and biotechnical companies 1 Private and public research organisations 1 medical institutions

products 1 tecHnologIes

genomic services:

1 next generation sequencing (roche/454 and illumina

highseq 2000)

1 re-sequencing of genes and/or genomic regions 1 library services

1 Cloning and sequencing

1identification of microorganisms 1 genotyping services

1 sanger Dna sequencing services

nucleic acid preparation:

1 nucleic acid extraction service (Dna, rna) 1 Kits for nucleic acid preparation (medium/high

throughput) contact lgC genomics gmbh ostendstraße 25 12459 berlin · germany Phone +49 30 5304 2200 fax +49 30 5304 2201 service@lgcgenomics.com www.lgcgenomics.com

Dr. steffen Krüger (managing Director) Werner von heimann (european sales and marketing manager)

(36)

Industry

CliniCal Chemistry

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immunoassay

1

moleCular DiagnostiCs

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hematology

1

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1

miCrobiology

1

Point of Care testing

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others

1

lImetec BIotecHnologIes gmBH Key fIgures 1 foundation: 2001 1 employees: 20 1 software development 1 system integration

1 Diagnostics for infectious diseases 1analysis of genetic predisposition

marKet segments

1infectious diseases 1 Pharmacogenomics 1 Cardiology

1 biomarker identification and validation

products 1 tecHnologIes

the company develops modern biomolecular methods and has brought already more than thirty innovative products on the market (Ce marked products).

1 high-speed and high-quality proof systems for the

detection of bacteria and viruses

1 Proof system for allelic discrimination detection for

hereditary diseases

1 high-sensitive and secure immunoblot for early

detection of lyme disease software and device

1 Creation of affordable communication solutions which

connect ambulatory (out-patient) and stationary (in-patient) care

1 limetec has developed lab@ccess, an innovative

web-based platform for laboratory orders. this innovative system provides versatile information, supports data exchange with the lab and makes cost transparency possible by allowing analyses of economic indicators.

major r&d-topIcs

1 Close-partnered – project tera-Diagnostic 1 mrsa detection

1allelic discrimination assays (taqman method) 1 Detection of human antibodies against borrelia 1 Drug resistance of mycobacterium tuberculosis

contact limetec biotechnologies gmbh ladeburger straße 17 16321 bernau · germany Phone +49 3338 694265 fax +49 3338 764440 www.limetec-biotechnologies.de

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Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

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1

others

1

medIpan gmBH

Key fIgures

1 Developing, manufacturing and distributing in

vitro-diagnostic assays in the field of organ-specific

autoimmunity like thyroid diseases and type 1 diabetes

1 market leader in type 1 diabetes diagnostic; inventor

and market leader of the aKliDes® system, first system for fully automatic evaluation for cell-based immunofluorescence tests

1 Currently distributing aKliDes®-assays for diagnostic

of systemic rheumatic diseases (hep2-cells, anCa and Crithidia)

1 regarding aKliDes® as a multiparameter platform

we are developing a bead system (ana and anCa diagnostic) and assays for other indications

1 european distributor of rapid tests (diabetes, liver

function, kidney function, urinary tract infection) for the use at home

1 operating worldwide marKet segments 1in vitro-Diagnostics products 1 tecHnologIes 1 elisa 1 ria

1(Digital) ifa (hep2 cells, anCa and Crithidia) 1 bead assays

major r&d-topIcs

1 Platform technology of aKliDes® system 1 bead assays contact medipan gmbh ludwig-erhard-ring 3 15827 Dahlewitz/berlin · germany Phone +49 33708 4417 0 fax +49 33708 4417 25 info@medipan.de www.medipan.de

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Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

-omiCs teChnologies

1

metanomIcs HealtH gmBH

Key fIgures

metanomics health – a basf group company – applies comprehensive metabolite Profiling (metabolomics) with biomedical data interpretation. metabolite Profiling is de-fined as the parallel analysis of multiple endogenous and xenobiotic metabolites in biological systems. the core expertise of metanomics health resides in discovery and validation of biomarkers.

marKet segments

metanomics health provides its services to pharmaceutical, diagnostics and nutrition companies. technology applica-tions include:

1 mechanism of action studies 1 mechanism of toxicity studies

1translational and clinical biomarker development

(e. g. PK/PD, patient stratification, efficacy and safety markers)

1 Companion diagnostic development 1 Cell culture and bioprocess optimization

products 1 tecHnologIes

1 metabolite profiling platform with more than 75 gC-ms

and lC-ms/ms instruments

1 Wide metabolite coverage via combination of unbiased

and targeted platforms

1 unique tox mode of action prediction through

metamap®tox database

1 excellence in systems correlation analysis of complex

gene function relationships

major r&d-topIcs

in cooperation with academic institutes and clinical ex-perts metanomics health is running a large-scale diagnos-tic biomarker program. areas include metabolic syndrome, heart failure, prostate cancer and multiple sclerosis to mention a few. contact metanomics health gmbh tegeler Weg 33 10589 berlin · germany www.metanomics-health.de

(39)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

mIcrodIscovery gmBH

Key fIgures

1 foundation: 2000 1 employees: 16

microDiscovery develops software and bioinformatics solu-tions for diagnostics, personalized medicine and molecular biology research. the portfolio also includes biostatistical data analysis and data management.

efficient proprietary algorithms are the basis for customer specific software for in vitro-diagnostics and medical tech-nology. software solutions can be developed as Ce-certified, fDa compliant (21 Cfr part 11) and iso 62304- compliant. microDiscovery is Din iso 9001:2008 certified by tÜV rheinland.

marKet segments

1 bioinformatics

1 software development for in vitro-diagnostics and

biomedical instruments

1 Data analyses for clinical and biological requirements

products 1 tecHnologIes

1 software development:

Customer-specific oem software development, algorithm development as well as biochips analysis software

1 Data analysis:

ngs/hts data analysis service and data mining

1 biostatistical analysis:

evaluation of clinical studies, assay validation and biomarker validation

1 Data management:

Database development and data integration

major r&d-topIcs

1 Development of multiparameter diagnostics 1 biomarker in complex diseases

1 systems biology for medical applications

contact microDiscovery gmbh marienburger straße 1 10405 berlin · germany www.microdiscovery.de Dr. arif malik

(40)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

mInerva BIolaBs gmBH

Key fIgures

1 foundation: 1999 1 employees: 15

minerva biolabs gmbh is a leading biotechnology com-pany for the development and production of molecular PCr-based iVD diagnostic and research kits for the detec-tion of microbial contaminadetec-tion in biopharmaceuticals and cell cultures and human pathogens. in addition we offer a broad range of testing procedures and elimination services for the pharmaceutical and biotechnology industry. our company is based in berlin and operates worldwide via numerous distributors.

to secure customers confidence, minerva biolabs has designed a strict quality management system that meets all requirements of the worldwide accepted quality standards iso 9001 and iso 13485.

marKet segments 1 molecular biology 1 microbiology 1 Diagnostics 1 Contamination control products 1 tecHnologIes

1 Contamination control: Detection and elimination

of microbiological contamination, disinfection

1 Clinical diagnostics 1 Water diagnostics 1 PCr supplements 1 enzymes

1 genomic Dna extracts 1 Quantification standards

major r&d-topIcs

Development and production of qPCr assays and applications in molecular biology.

contact

minerva biolabs gmbh

Köpenicker straße 325, haus 12 12555 berlin · germany

Phone +49 30 2000 4370 fax +49 30 2000 4379 info@minerva-biolabs.com www.minerva-biolabs.com Dr. Dirk Vollenbroich (Ceo)

(41)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

peptIdes&elepHants gmBH Key fIgures 1 foundation: 2001 1 employees: 10, PhD: 3 marKet segments

synthesis technology made in germany

peptides&elephants – We serve Peptides – for your perfect satisfaction with quality, price and support. our major PeP-liPs products are high parallel customized peptide libraries and peptide pools. PeP-liPs are approved for t-Cell stimulation assays, epitope mapping, elispot assays, Drug Discovery and array technology. the full range of Peptides and Peptidomimetica from the single to millions from linear to cyclic from short to overlong, from crude to high purity, from modified to labeled, from natural to non natural amino acids – peptides&elephants are your faithful partner. contact peptides&elephants gmbh am mühlenberg 11 14476 Potsdam · germany Phone +49 331 50570110 fax +49 331 50570120 info@peptides.de www.peptides.de

(42)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

polyan gmBH

Key fIgures

1 foundation: 1996 1 employees: 16

Polyan is specialised in molecular surface engineering (mse) and surface molecular imprinting (smi). Polyan’s proprietary mse-technology platform is used in the pro-duction of biochips, microparticles and nanoparticles as well as membranes. Polyan’s surface functionalisation op-timises the performance of analytical processes by improv-ing the signal-to-noise ratio, the reproducibility and also enabling new combinations of surface functionality and base material.

products 1 tecHnologIes

Polyan offers a range of surface functionalised consum-ables for multiplex diagnostics and lifescience research:

1 functionalised microarray slides (both glass and plastic)

and 96-well plates with 3D-reactive surfaces for Dna, aptamere, peptide and protein arrays.

1 fluorescence encoded Pmma microparticles (beads) for

multiplex bead arrays and other applications. the beads are adapted to the most commonly used detection systems, e. g. flow cytometry, image cytometry and microscopy systems, respectively.

based on extensive experience in research and develop-ment of surfaces Polyan also offers tailor-made solutions for specific customer applications, e.g. surface modified tubes, membranes, sinter and fleece materials, as consum-ables for a wide range of applications in lifescience and other industries. contact Polyan gmbh rudolf-baschant straße 2 13086 berlin · germany Phone +49 30 912078 0 fax +49 30 912078 11 mail@poly-an.de www.poly-an.de fridtjof lechhart

(43)

Industry

CliniCal Chemistry

1

immunoassay

1

moleCular DiagnostiCs

1

hematology

1

Coagulation

1

miCrobiology

1

Point of Care testing

1

others

1

proteome factory ag

Key fIgures

1 foundation: 2000 1 employees: 7

Proteome factory is specialized in protein analysis, pro-teomics and development of multiplex meCat – metal linked immunoassays.

1 Contract research: amino acid (de novo) sequencing

of proteins & antibodies, protein sequence verification and identification, characterization of Ptms, ss bridges, glycopeptides, 2De and ms-based host cell protein assays, quality control of proteins and peptides, protein quantitation

1 biomarker finding, proteomics, immuno-, phosphor-,

membrane- proteomics: 2De, itraq, mudPit etc.

1 fee-for-service: 2De, protein identification, protein

analysis, n-terminal aa sequencing, high resolution mass spectrometry, nanolC-esi-msms

1 Development of meCat immuno and bioimaging assays

marKet segments

1immunoassay

1 Contract research services

products 1 tecHnologIes

1 meCat – metal coded tagging reagents for

ultra-sensitive multiplex assays of proteins and antibodies

1 firesilver ms compatible gel silver staining 1 de novo peptide sequencing software sequit!

major r&d-topIcs

1 Development of ultra-sensitive meCat multiplex assays

for bioimaging and immuno assays

1 r&D in allergy 1 Proteomics contact Proteome factory ag magnusstraße 11 124

References

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