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Investigations of Pyrrole Imidazole Polyamide Effects on DNA Replication

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Figure

Figure 1.1 Structure of DNA and hydrogen bonding patterns of Watson-Crick base pairs. (A) Structure of B-form DNA (PDB 1BNA) (4)
Figure 1.3 Chemical structures of DNA-binding small molecule natural products.  
  
Figure 1.4 Structures of distamycin A bound to DNA. (A) Structure of 1:1 complex of distamycin with DNA (PDB 2DND) and a schematic of distamycin binding to the minor groove in the 1:1 mode
Figure 1.5 Molecular recognition of DNA by Py-Im polyamides. (A) Schematic of Py-Im polyamide targeted to 5’-WGWWCW-3’ binding to the minor groove
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