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Ellis Englesberg and the Discovery of Positive Control in Gene Regulation

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Figure 1 Ellis Englesberg in his laboratory at University of CaliforniaSanta Barbara (UCSB), 1986
Figure 2 Theof genes and regulatory sites in the ara operon. Themapped position ofremoves thefor positive and negative control of the araBADgenes by AraC
Figure 3 Present-day model for regulation of the ara operon. (A) In theabsence of arabinose, the AraC N-terminal dimerization domain is con-strained and favors binding of AraC to distant sites, forming a DNA loopbetween the araI1 and araO2 sites

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