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Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem

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Figure

Figure 1 characteristics of DMsa-MnPs (A), anti-cD22-MnPs-DOX (B), and particle size distribution (C) under electron microscopy.Abbreviations: ab, antibody; DMsa, dimercaptosuccinic acid; DOX, doxorubicin; MnPs, magnetic nanoparticles.
Figure 2 in vitro release of doxorubicin from anti-cD22-MnPs-DOX.Notes: The drug release rate at pH 5.6 is significantly different from that at normal ph
Table 2 ic50 values for DOX-sol, DOX-MnPs, and anti-cD22-MnPs-DOX at 24 and 48 hours (mean ± standard deviation, n=3)
Figure 5 Apoptosis rates of Raji cells for 24 hours by flow cytometry.Abbreviations: DaPi, 4′,6-diamidino-2-phenylindole; FITC, fluorescein isothiocyanate; DOX, doxorubicin; MNPs, magnetic nanoparticles; Sol, solution; Comp, compound.
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