Photosynthesis & Chloroplasts
6CO₂ + 6H₂O C₆H₁₂O₂ + 6O₂
Heterotroph – something which gets its food from other organisms Autotroph – creates its own food
Photoautotroph – uses light & energy to create its own food ATP - Adenosine Triphosphate (3 phosphate groups)
- Universal energy source.
- Powers cellular processes by building and breaking bonds
When we need energy, the third bond is broken by a hydrolysis reaction using ATPase enzyme.
ATP ADP + Pi + energy The Electron Transport Chain
ATP is made as a result of what is used in the electron transport chain. As electrons move along the chain, they lose energy which can be used to drive the synthesis of ATP to ADP & inorganic phosphate.
Hydrogen molecules removed from compounds are picked up by other
compounds and become reduced. – OILRIG (oxidation is loss, reduction is gain)
Chloroplasts: Structures & Functions
Starch Grain Organelle which contains starch
Lamellae Extension of the Thylakoids (contain
PSI)
Thylakoids Organelle which contains chlorophyll
(and PSI & PSII) found in the Stroma in stacks called Grana. Increase surface area for light capture and allows
capture of photons with a wider range of wavelengths. Light Dependant Reactions occur in the Thylakoid Membrane.
Grana (granum) Stack of Thylakoid discs
Stroma The space in a chloroplast surrounding
the Thylakoids. Contains ribosomes and genetic materials so proteins required for photosynthesis can be synthesised. Also contains starch grains and lipid droplets.
Ribosomes Organelle for synthesis of
Polypeptides Outer Membrane
(double membrane)
Permeable to most ions and metabolites.
Inner Membrane (double membrane)
Highly specialised with transport proteins
Chlorophyll Pigments There are 5 pigments:
- Chlorophyll a - Chlorophyll b - Carotene - Xanthophyll - Phaeophytin
All parts of the plant do not need to carry out photosynthesis and therefore do not have chloroplasts. The most abundant type of chlorophyll is ‘chlorophyll a’ which is found in most places. The benefit of having different types is that it is most efficient as each of the pigments absorbs and captures light from particular areas, more energy from the light can be used and photosynthesis is maximised. Plant leaves appear green as all colours apart from green are absorbed so green is reflected back as chlorophyll a is most abundant.
Carotenoids
Photosystem I – Lamellae Photosystem II – Granum
Light dependent reactions – Thylakoid Membrane Light independent reactions – Stroma
LIGHT DEPENDENT REACTIONS
Products of Light Dependent Reactions - ATP (energy), Oxygen & Reduced NADP
Takes place on the thylakoid membranes of the chloroplasts. It has 2 main functions:
1. To produce ATP, supplying energy for the synthesis of carbohydrates 2. Split water molecules in a photochemical reaction providing hydrogen
ions to reduce CO2 & produce carbohydrates
The smallest unit of light energy is a photon. When a photon of light hits a chlorophyll molecule, the energy is transferred to the electrons of that molecule. Photoexcitation occurs & if an electron is raised to a sufficiently high energy level it will leave the chlorophyll molecule completely. The excited electron can be picked up by an electron acceptor (carrier molecule). This in turn results in the synthesis of ATP by one of two processes – Cyclic & Non-Cyclic photophosphorylation.
CYCLIC PHOTOPHOSPHORYLATION
Cyclic photophosphorylation involves only photosystem I & drives the production of ATP. When light hits a chlorophyll molecule, a light excited
electron leaves the molecule. It is taken up by an electron acceptor and passed directly along the electron transport chain to produce ATP. When an electron returns to the chlorophyll molecule in PSI, it can then be excited in the same Way.
NON - CYCLIC PHOTOPHOSPHORYLATION
Non cyclic photophosphorylation involves both photosystem I & photosystem II. It splits water molecules to provide reducing power to make carbohydrates. It also produces more ATP.
Water dissociates into Hydrogen (H+) ions and hydroxide (OH-) ions, so there are always plenty of these ions present in the cell. A series of Redox Reactions take place.
An excited electron from PSI is picked up by an electron acceptor (NADP). The NADP takes up a hydrogen ion from the dissociated water at the same time to form reduced NADP. This reduced NADP is used as a source of reducing power in the light independent reactions of photosynthesis to make glucose.
At the same time, an excited electron from PSII is picked up by another
electron acceptor and passes along an electron transport chain until it reaches PSI. PSI then receives an electron to replace the one that was lost to the light independent reactions.
As the chlorophyll molecule in PSII is short of an electron and unstable, an electron has to be found from somewhere to restore the chlorophyll to its original state. The electron comes from the splitting of water – PHOTOLYSIS.
LIGHT INDEPENDENT REACTIONS
Carbon dioxide is converted to carbohydrates. These reactions
occur in the Stroma of the chloroplasts, surrounding the grana.
Carbon dioxide readily diffuses into the chloroplast where it is built
up into sugars in a cyclic process called the Calvin cycle.
The Calvin Cycle
Intermediates of the Calvin Cycle:- RuBP (Ribulose Biphosphate)
- Rubisco (Ribulose Biphophate Carboxylase/Oxygenase enzyme) - GP (Glycerate 3 – phosphate)
- TP (Triose phosphate) = GALP (Glyceraldehyde 3 phosphate)
- The enzyme Ribisco combines RuBP with CO₂ to form a 6 carbon molecule (unstable) which then splits into 2 GP molecules which are 3 carbons each. - These molecules are reduced using ATP energy & H+ from NADPH (from
the light dependent reactions) to form 2 GALP molecules (3 carbons each). - 1 carbon goes off to make complex molecules; glucose, lipids and amino
acids & the other 5 start the process again converting back into RuBP.
- Products of the Calvin Cycle which pass from independent reaction to dependent reactions are: NADP, ADP & Inorganic Phosphate
ECOSYSTEM
- An ecosystem is a life supporting environment which includes all living organisms which interact together, the nutrients that cycle through the system, and the physical & chemical environment in which the
organisms are living.
Habitat – place where an organism lives
Population – group of organisms of the same species
Community – all the populations of different species living in a habitat at any one time.
Niche – role of an organism, its way of life
Abiotic factors – non-living elements of the habitat of an organism e.g. sunlight, temperature, soil, ph.
Biotic factors – living elements of a habitat which affect the ability of a group of organisms to survive there e.g. the presence of suitable prey will affect the number of predators in the habitat
BIOMES
- Major ecosystems devised from the biosphere, distinguished by their similar climates and plant communities.
Tropical Rainforest – high humidity, warm and plenty of sunlight, rain all year. Savannah – dry tropical grassland
Tropical Woodland – wetter than savannah, grassland with thornwoods, bushes and trees
Desert – very little rainfall, often extreme of temp. between day and night Taiga – evergreen forests in cold subarctic & subalpine regions
Tundra – very cold, artic & high mountain regions
The major biomes have developed over millions of years due to:
SUCCESSION -
Communities of animals and plants colonise an area, and over time are replaced by other, usually more varied communities
Primary Succession –
- Rock is uninhabited, due to poor conditions for growth such as no soil or moisture
- Pioneer species such as algae or lichens penetrate the bare rock
- The pioneer species break the bare rock, this is mixed with the remains of dead pioneer species organisms – HUMUS, which creates the
foundations of soil
- Once soil is established, plants which require soil such as grasses and ferns colonise the area
- Upon the death of primary colonisers, more humus is added to the soil, so the nutrient content develops. Roots hold the soil together and retain more water
- Secondary colonisers more adapted to the new environment will then colonise the land
- Larger trees block the growth of smaller plants, due to competition for sunlight & species diversity drops.
- Climax community is self-sustaining & reached where the biodiversity is constant. Not many further changes occur.
Secondary Succession –
Occurs as rivers shift their courses after fires & floods and disturbances cause by humans. Due to primary succession, the soil is already formed and contains the seeds, tools and soil organisms, which means the number of plants and animals present right from the beginning of the succession, are much higher.
EFFECTS OF
ABIOTIC
FACTORS
ABIOTIC FACTOR EFFECT ON ECOSYSTEM IF IN
MODERATION
EFFECT ON ECOSYSTEM IF TOO MUCH/LITTLE
Light
Plants depend on light forphotosynthesis and must be able to cope in areas with
low levels of light.
Some plants are able to reproduce and thrive in low light levels, having
extra chlorophyll or other chlorophyll pigments which are
sensitive to lower light levels. Animals’ behaviour may be affected by seasonal light changes, as well as
reproductive patterns.
Temperature
There is a range oftemperatures which allow growth and reproduction for
particular organisms. The temperature in an area also
affects the rate of enzyme controlled reactions in plants
Above or below that range, reproduction does not occur, even if
the organism survives. It is the extreme of temperature which determines where an organism can
live, not the average.
Wind
Wind increases water andheat loss from the body ad adds to the environmental stress an organism has to
cope with.
Few species can survive in areas with strong prevailing winds while occasional gales and hurricanes can
devastate populations.
Water
Water is vital for livingorganisms
So where the supply is limited it will cause severe problems. Organisms
may die if the stress becomes too severe if like camels and cacti, the have adaptations to enable them to
survive.
Oxygen Conc.
Oxygen can be in shortsupply in both water and soil. When water is cold sufficient oxygen dissolves in
it to support life and vice versa. Soil is usually well
aerated.
The spaces between soil particles contain air so there is plenty of oxygen for the respiration of plant
roots. In waterlogged soil, the air spaces are filled with water so plant
roots may be deprived of oxygen and may die.
Edaphic
Factors (soil
structure &
mineral
content)
Plant populations that are linked by massive root and rhizome networks, such as marram grass can survive in
loose, shifting structures such as sand. They bind the sand together which makes it
more suited for colonisation by other species.
Soil that contains high proportion of sand are light, easily worked and
warmed. However, also easily drained so water passes through them rapidly, carry with it minerals
needed for plants. The opposite occurs for soils made of predominantly tiny clay particles.
EFFECT OF
BIOTIC
FACTORS
TERM & MEANING
HOW IT AFFECTS
AN ECOSYSTEM
EXAMPLE
Finding a mate –
finding a member of
the opposite sex to
reproduce with
Affects the
biodiversity –
allows niches to
carry on. Larger
allele/genetic
diversity
A equine species
becoming extinct
due to
reproduction
isolation
Territory – an area
occupied & defended
by an/a group of
organism (s) from
the same or different
species
Resources are
defended making
sure others can get
them and continue
reproducing
Lions ‘dens’
Parasitism & Disease
– biotic factors which
cause weakened
animal relationships.
Where 1 organism
benefits at the
others expense
Diseases can wipe
out whole
populations within
a biome
Mixing
populations &
bringing diseases
– Wild pigs
Competition –
-
Intra
specific Competition –
competition for a limited
resource between
members of the same
population or species.
As a result of intraspecific
competition, some
individuals may not
survive, or may not
reproduce and so
population growth slows.
-
Inter
specific Competition – occurs when different species
within a community compete for the same resources.
Competition will reduce the abundance of the competing
species.
Energy Transfer In Ecosystem
Gross Primary Productivity (GPP) – the rate at which energy is incorporated into plants. Plants use up to 25% of this accumulated energy for metabolic processes. Most importantly, in respiration – breaking down glucose to release energy in the form of ATP.
Net Primary Productivity (NPP) – The rest of energy which is stored in body tissues
NPP = GPP – Plant Respiration
The energy in plant material is available to herbivores, but relatively little of it ends up as new animal material. Much of the energy is used to drive
respiration then is lost to the atmosphere as heat energy. Some is lost as chemical energy in metabolic waste products and heat energy in urine. The energy used to make new animal biomass is known as SECONDARY PRODUCTION.
Speciation & Evolution
Mechanisms of Speciation –
Populations that have been isolated for millions of years can remain effectively the same species. However,populations living next door to each other can begin to form new species. Reproductive isolation is crucial to speciation and this occurs when fertilisation is prevented (prezygotic) or when the zygote fails or is unable to breed
(postzygotic) Allopatric Speciation – Occurs when populations are geographically far
Sympatric Speciation – Occurs when populations are geographically near but other barriers prevent
reproduction such as:
Prezygotic
Reproductive Barriers
Postzygotic
Reproductive Barriers
Gametic Isolation – Sex cells of opposite sexes are incompatible
-
Behavioural Isolation – Speciation populations do not respond to each others mating calls-
Mechanical Isolation – Reproductiveorgans do not fit together with all potential members of the same species
-
Temporal Isolation – Species exist in the same area but are reproductively active at different times of the year-
Habitat Isolation – Populations occupy different habitats in the same area, and therefore do not breed-
Hybrid Infertility – Offspring of two different species are not fertile-
Low Hybrid Zygote Vigour – Zygote fails to develop and dies or producesoffspring with severe disability
-
Low Hybrid Adult Viability – Offspring of two different species are not healthy enough to surviveINVESTIGATING TIME OF DEATH
A number of changes take place in the place of any mammal after
death which can be helpful in estimating the time of death.
- The normal human body temp is 37°C, at death the metabolic
reactions which have created the body heat slow down and
eventually stop. Although body temp. Starts to fall straight
after death, it plateaus for a while before dropping steadily to
room temp. As a result, the temp. of a body will give some
indication of how long they have been dead.
Rigor Mortis – a stiffening effect caused by lack of ATP in the
muscles & muscle fibres becoming permanently contracted and
locked solid. On average rigor mortis starts about 2-4 hours after
death, begins in the face & neck and works its way down the body.
Stages of Succession
- The first colonisers are anaerobic bacteria, which do not
need oxygen and thrive in the lactic acid rick
environment of the muscles after death.
- As enzymes break down cells, the bacteria spread & are
joined by several species of flies – mostly blowflies.
These insects can arrive on the body within minutes of
death as they are attracted to the moisture and smell of
natural orifices of the body as well as open wounds.
- The main attraction of the body is a site to lay eggs.
Maggots begin to hatch and feed on the tissues,
breaking them down.
- The maggots pupate, turn into flies, mate & start the
cycle again. As the tissues of the body liquefy, adult flies
can feed on this too.
- Beetles then begin to lay eggs on the carcass & parasitic
wasps arrive to lay their eggs in the larvae.
- As the body is digested it also dries out, which doesn’t
suit the early colonisers. Different species such as the
cheese flies and coffin flies move in.
- As the body becomes too dry for maggots, carcass
beetles, ham beetles and hide beetles feed on the
remains of the muscles and connective tissues
- At the very end, mites and other larvae will feed on the
Viruses
- Viruses are the smallest of
all microorganisms. They
are not cells, but
arrangements of genetic
material and protein that
invade other living cells &
take over their
biochemistry to make
more viruses.
- Most scientists class viruses as obligate intracellular
parasites meaning they can exist and reproduce as
parasites only in the cells of other living organisms.
The Structure of Viruses
The protein coat or
capsid is made up of
simple repeating
protein units known
as capsomeres,
arranged in different
ways. In some viruses,
the genetic material
and protein coat are
covered by a lipid
envelope, produced
from the host cell. The presence of the envelope makes it
easier for the viruses to pass from cell to cell but it does
make them vulnerable to substances such as ether which will
dissolve the lipid membrane. Viral genetic material can be
DNA or RNA, and nucleic acid can be single or double
stranded.
Viral RNA directs the synthesis of a special enzyme called
reverse transcriptase which proceeds to make DNA
molecules corresponding to the viral genome.
Viruses attach to their host cells by means of specific
proteins (antigens) known as Viral attachment particles
(VAPs) which target proteins in the host cell surface
Virus Life Cycles
Bacteriophages inject their genome into the host bacterial
cell but the bulk of the viral material remains outside the
bacterium. The viral DNA forms a plasmid within the
bacterium. The viruses that infect animals get into the cells in
several ways. Some types are taken into the cell by
endocytosis & the host cell then digests the capsid, releasing
the viral genetic material. The viral envelope fuses with the
host cell surface, releasing the rest of the virus inside the cell
membrane. Plant viruses usually get into the plant cell using
a vector (often an insect) to pierce the cellulose cell wall.
2 routes of infection
- Lysogenic Pathway – Many viruses are non-virulent
when they first get into the host cell. They insert their
DNA into the host DNA so it is replicated every time the
host cell divides. This inserted DNA is called a provirus.
During this period of lysogeny, when the virus is part of
the reproducing host cells, the virus is said to be
dormant.
- Lytic Pathway – Sometimes the viral genetic material is
replicated independently of the host DNA straight after
entering the host. Mature viruses are made & eventually
the host cell bursts, releasing large numbers of new
virus particles to invade other cells. The virus is said to
be virulent (disease causing) & the process of
replicating & killing cells is known as the lytic pathway.
1. Bacteriophage attracts bacterium
2. Phage DNA is injected into host cell. It brings about
the synthesis of viral enzymes
3. A. Viral DNA is incorporated into host cell DNA &
replicated each time the bacterium divides, without
causing any damage.
B. OR Phage DNA inactivates the host DNA and takes
over the cell biochemistry
4. Phage DNA is replicated. New phage particles are
assembled as new protein coats are made around
phage DNA. The enzyme lysozyme is synthesised or
released
5. Lysis – the bacterial cell bursts due to the action of
lysozyme, releasing up to 1000 phages to infect other
bacteria & the cycle begins again.
RETROVIRUSES
Retroviruses have a more complex life cycle. Their
genetic material is viral RNA. This cannot be used as
mRNA but is translated into DNA using reverse
transcriptase.
1. The retrovirus attacks an animal cell
2. Viral RNA enters the host cell. This RNA cannot be
used as mRNA.
3. Viral RNA is translated into viral DNA by reverse
transcriptase in the cytoplasm
4. Viral DNA is incorporated into the host DNA in the
nucleus. It directs the production of new viral genome
RNA, mRNA and coat proteins.
5. New viral particles are assembled and leave the host
cell by exocytosis. Viral DNA remains in the nucleus
so the process is repeated.
6. The host cell continues to function as a virus making
factory, while the new viruses move on to infect
other cells.
Bacteria
Cell Wall –
Protects against rupture due to osmosis and keep shape. Rigid wall containing giant molecules
consisting of amino sugars and peptidogylcan
Cytoplasm - About 75% water in which are dissolved
proteins (mainly enzymes) Lipoproteins, sugars, amino acids and fatty acids, inorganic salts, and the waste products of metabolism.
Capsule – A slime layer or capsule is made up of additional materials that are laid down on the outer surface of the wall. Capsules are firmly attached, whereas slime layers may diffuse into the surrounding medium.
Flagella & Pilli –
Flagella are rigid protein strands that arise from basal bodies in the plasma membrane in some bacteria. They bring about movement by rotating from their base, driven by the basal body.
Pilli are tiny tubular structures that arise from the cell membrane of some bacteria. They enable bacteria to attach to surfaces and to other bacteria.
Mesosomes –
Infoldings of the plasma membrane found in some bacterial cells. In the
photosynthetic bacteria, they are where the photosynthetic pigments are housed.
Plasmids –
Additional hereditary material – small rings of DNA, present in the cytoplasm of some but not all bacteria.
Plasma Membrane - Consists of phospholipids and proteins arranged in the fluid mosaic model. Carbohydrates attach to some lipids forming glycolipids and some proteins forming glycoproteins on the outer surface membrane.
Ribosomes - Sites of protein synthesis. Bacterial ribosomes are known as 70S ribosomes because they are smaller than those in the
cytoplasm of plant and animal cells and fungi (called 80S ribosomes)
There are two different types of
bacterial cell walls which can be
distinguished by Gram Staining.
Gram positive bacteria have a thick
layer of peptidoglycan containing
chemicals such as teichoic acid. The
crystal violet in the stain binds to
the acid & resists decolouring,
leaving the positive PURPLE/BLUE in
colour.
Gram negative bacteria have a
thinner layer of peptidogylcan with no teichoic acid. Any crystal
violet which does bind is readily decolourised & replaced with red
safranine in the stain, so the cells appear
RED
in colour.
Classifying Bacteria
- by shape
Cocci (spherical)
Bacilli (rod shaped)
Spirilla (twisted/spiral)
Vibrios (comma shaped)
Reproduction of Bacteria
Bacteria can reproduce in two main ways. The most common
is Asexual Reproduction (binary fission) splitting into two.
One the bacterium reaches a certain size, the DNA is
replicated and the old cell wall begins to break down around
the middle of the cell. Enzymes break open the circular piece
of DNA allowing the strands to unwind and be replicated.
Another form of reproduction is Sexual reproduction. In very
rare conditions, bacteria can reproduce using what appear to
be different forms of sexual reproduction. There are 3 ways
in which genetic material from one bacterium cab be taken in
and used as part of the DNA of another bacterium.
Transformation –
A short piece of DNA is released by a donor and actively
taken up by a recipient where it replaces a similar piece of
DNA. Only occurs in certain types of bacteria.
Transduction –
Takes place when a small amount of DNA is transferred from
one bacterium to another by a bacteriophage. Bacteriophage
attaches to the bacterial cell wall. Enzymes are released to
break down the cell wall. New bacteriophage forms and
some bacteria DNA is included by mistake
Conjugation – genetic information is transferred from one
bacterium to another by direct contact. The donor cell is
similar to a male cell and this produces a sex pillus, a
cytoplasmic bridge between the two cells through which DNA
Endotoxins –
- Lipopolysaccharides (part of the outer layer of gram negative bacteria) - Rarely fatal
- Tend to cause symptoms such as fever, vomiting & diarrhoea
- E.g. Salmonella & E.coli - However symptoms may
indirectly lead to death Exotoxins
- Soluble proteins produced & released into the body by bacteria as they metabolise and reproduce.
- There are many different types; some damage cell membranes causing internal bleeding, some act as competitive inhibitors to
neurotransmitters, whilst others directly poison cells.
- Rarely cause fevers but so include some of the most dangerous bacterial diseases.
- E.g. Clostridium botulinum produces one of the most toxic substances known, botulinum toxin
BENEFICIAL BACTERIA
- Many bacteria in the body is beneficial, helping to break down food and keeping pathogens at bay by outcompeting them. The normal growth of bacteria on your skin or in your gut is referred to as the ‘skin flora’ or ‘gut flora’
-
Probiotic drinks and foods contain cultures of these ‘good’ bacteria to help support the normal healthy bacterial flora of the gut.
- Bacteria also play a vital role in the ecosystems of the natural world. The majority of bacteria are decomposers. They break down organic
material to produce simple inorganic molecules such as CO2 and water. - They release inorganic nitrogen which returns to the soil in the nitrogen
cycle, and also sulphur compound which returns to the soil or water. - Another important aspect of bacteria is in the carbon cycle is the fact
that some microorganisms produce the enzyme cellulase. This enzyme breaks down the cellulose produced in plant cell walls to give sugars which can then be used as food by a wide range of other
INVADING THE BODY
Pathogens are transmitted in a variety of ways:
- Vectors - a living organism that transmits infection from one host to another E.g. Insects – Malaria
- Fomites – inanimate objects that carry pathogens from one host to another E.g. Hospital towels & bedding
- Direct Contact – many sexual diseases are spread by direct contact of genital organs E.g. Gonorrhoea or Syphilis
- Inhalation – coughing, sneezing, & talking release droplets which contain pathogens E.g Tuberculosis & Influenza
- Ingestion – Contaminated food – the risk is greatest in raw or undercooked food E.g. Salmonella
- Inoculation – directly through a break in the skin either through
contaminated medical instruments or shared needles in drug abuse. An infected animal may also bite or lick you. E.g. H.I.V or Rabies
BARRIERS TO ENTRY
SKIN
- An impenetrable layer toughened by keratin, a fibrous structural protein
- Forms a physical barrier between the pathogen laden environment & the blood rich tissues beneath the skin
- Sebum, an oily substance produced by the skin contains chemicals which inhibit the growth of microorganisms
- Natural skin flora prevent disease by competing successfully for a position on the skin & produce substances that inhibit the growth of other microorganisms
MUCUS & TEARS
- Surfaces of internal tubes & ducts are more vulnerable than skin
however these epithelial layers also produce defensive secretions. Many produce MUCUS.
- MUCUS contains lysozymes, enzymes capable of destroying microbial cell walls, particularly against gram positive bacteria, breaking cross linkage in the the peptidoglycans in the bacterial cell wall.
- Lysozymes are also present in tears, the secretions produced to keep the eyes moist & to protect them from the entry of pathogens.
- Part of the non-specific defence of the body
GUT
- Saliva in the mouth has bacterial properties. Some polypeptides
produced in the salivary glands destroy bacteria while others slow down bacterial growth.
- Acid in the stomach destroys the majority of ingested microorganisms. - The natural flora in the gut usually competes successfully for both
nutrients and space with any microorganisms which manage to get through the stomach & produces anti-microbial compounds
- VOMITING is effectively removing many of the microorganisms physically from the system when the body is infected.
NON SPECIFIC RESPONSES TO INFECTION
Inflammation is a common way in which our bodies respond to infection. - Special cells called mast cells are found in the connective tissue below
the skin & around blood vessels. When this tissue is damaged, mast cells along with damaged white blood cells release chemicals known as
HISTAMINES.
- These cause the blood vessels in the area to dilate, causing local heat & redness. The raised temp. reduces the effectiveness of pathogen
reproduction in the area.
- Histamines also make the walls of the capillaries lady as the cells forming the walls separate slightly. As a result, fluid including plasma, WBCs & antibodies is forced out of the capillaries causing swelling.
- The WBCs & antibodies destroy the pathogens.
Fever occurs when a pathogen infects the body which cause the hypothalamus to reset to a higher temp. This helps in 2 ways:
- A raised temp. will reduce the ability of many pathogens to reproduce effectively & so they cause less damage.
- Specific response works better at a higher temp. & therefore will be more successful at combating the infection.
Phagocytosis involves white blood cells. There are 2 main types of white blood cells; the granulocytes which have granules that can be stained in their
cytoplasm & agranulocytes which have no granules. - Phagocyte is a general term for white blood cells
which engulf & digest pathogens and any other foreign material in the blood & tissues.
- There are two types of phagocytes; neutrophils which are granulocytes & make up 70% of the white cells & macrophages which are
agranulocytes and make up about 4%. They accumulate at the site of infection to attack invading pathogens. Phagocytes can sometimes be seen as pus which may ooze out of the wound or it may be reabsorbed into the body.
NEUTROPHIL
MACROPHAGE
INTERFERONS – Group of chemicals produced when cells are invaded by viruses. Interferons are proteins that inhibit viral replication within the cells. They bind to receptors in the surface membranes on uninfected cells, stimulating a pathway which
THE SPECIFIC RESPONSE TO INFECTION
The immune system enables the body to recognise anything that is non-self and to remove it from the body as efficiently as possible. Each organism carries its own unique antigens or the cell surface membrane. There are 2 main types of White blood cells involved in the immune systems;
- Lymphocytes are agranulocytes, made in the white bone marrow - Macrophages are also agranulocytes which move freely through the
tissue after leaving the bloodstream
KINDS OF LYMPHOCYTES B cells
- are made in the bone marrow - found in lymph glands & free
in the body
- have membrane bound
globular receptor proteins on their cell surface membrane which are identical to the antibodies they will later produce
- all antibodies are known as immunoglobulins (IgM) T cells
- made in the bone marrow but mature and become active in the thymus gland
- Surface of each T cell displays thousands of identical T-cell receptors. There are 2 main types of T-cells; T killer cells – produce chemicals that destroy pathogens & T helper cells – involved in the process which produces antibodies against the antigens on particular pathogen. The working of these cells depend on special proteins known as major histocompatibility complex (MHC) proteins, which display antigens in the cell surface membranes
Helper Cells B Cells T Cells Killer Cells Lymphocytes
ANTIBIOTICS
- Bacteriostatic – the antibiotic used completely inhibits the growth or the microorganism
-
- Bactericidal – the antibiotic used will destroy almost all of the pathogens present
DIFFERENT TYPES OF IMMUNITY
- Natural Active Immunity – when the body comes into contact with a foreign antigen and the immune system is activated & antibodies are formed & the pathogen is destroyed. The body actively makes the antibodies.
- Natural Passive Immunity – during pregnancy, preformed antibodies are passed from the mother to the foetus through the placenta. The baby gets extra protection from antibodies taken in through breast milk. This provides the baby with temporary immunity until its own system
becomes active.
