1038
PEDIATRICS
Vol. 62 No. 6 December 1978and gasoline engines-to children, who lack both the maturity of judgment and the “motor skills” to control these vehicles?
There are other reasons for justified
exaspera-tion. Not only the excitement of high speeds gets into kids’ blood-the effiuvia from a forest of
tailpipes does also. I doubt that tetraethyllead,
sulfur dioxide, and carbon monoxide from a
weekend of trail-biking or snowmobiling en-hances a child’s learning capacity. That the stuff is not recommended for healthy lungs, there’s no question.
\Vhat of the values that our niotor-hungry
children are imbibing? Speed and power, not
esthetics or self-achievement, are the important goals. Independence and autonomy, not sharing
and cooperation, are stressed. Terrorizing other
people is more fun than interacting constructively with them. High-priced activities, like steering a
motorboat or bouncing on a snowmobile, are
exciting; inexpensive pursuits, like hiking or
swimming, are dull. Environments are prized
according to the availability of roads to haul
minibikeladen trailers and fuel stations to feed
gasoline tanks. Tranquility, isolation, and natural
beauty become quaint irrelevancies. Rather than drawing closer to the earth, appreciating its
smells and sights and sounds through noncon-sumptive and nondestructive pursuits, the object
is to get across territory in the fastest, loudest, and scariest way possible.
Finally, how much can a family share when all
its members are driving off in different directions
on their own vehicles? If parents bought their kids
skis instead of snowmobiles, bicycles instead to
trailbikes, the money saved could pay for more
life-enhancing motor activities-dance classes or
piano lessons, for instance. Better yet, parents
might save enough money to be able to spend a few extra nights or weekends with their children,
skiing, walking, or just talking with each other.
Kids might discover that their parents are more interesting people than they suspected, and parents might find that their children have much to teach them.
If I had my way, child-sized motor vehicles simply wouldn’t be nianufactured. Just as many states have outlawed the sale of dangerous
fire-works, so, too, could federal or state legislation
forbid the sale of these vehicles. Even without
additional legislation, the Consumer Product Safety Conilnission has the power to recall and
ban hazardous products. Perhaps if they received
enough letters from physicians treating children with motor-vehicle related injuries, they’d be
prompted to act. Finally, no person should be allowed to pilot aiiij motor-driven vehicle-on or off public roads or across waterways or in the
air-without a license.
Until these vehicles are no longer available to children, we as pediatricians can provide antici-patory guidance to parents, to steel them for the inevitable demands of their children for these “presents. ‘ ‘ Children will not become
demoral-ized if they’re demotorized, nor will they be
emotionally or physically deprived. Just as tod-diers will desert their fancy “educational” toys for hours of blissful play with battered pots and pans,
so will our adolescents find more gratifying, and
safer, pursuits. What’s required is for parents to
stop living out their fantasies, expiating their guilt, or avoiding their responsibilities by
lavish-ing on their children spirit-stifling, environment-destroying, hazardous, and expensive “toys.”
LAWRENCE R. BERGER, M.D.
Robert Wood Johnson Clinical Scholars Program,
University of Washington HQ-18
Seattle, WA 98105
REFERENCES
1. Boating Statistics, 1976, publication CG-357. US Coast Guard, May 1977.
2. \‘ationa! Electronic injury Surveillance System, Matrix
Report. US Consuiiier Product Safety Commission, Bureau of Epidemiology, February 1978.
Measles
immunization:
12 or 15 months?
The objective of immunization is to reduce morbidity produced by natural illness. Ideally, we
would like to eradicate natural infection. This goal, which has been presumably accomplished for smallpox, has clearly eluded us in the case of
measles. Eradication requires reduction in the
number of susceptible subjects to the point where transmission of natural infection is interrupted. It
is clear in the case of measles that we continue to have pockets of susceptible subjects that permit
perpetuation of this disease. Clusters of cases
occur in neighborhoods where immunization levels are low and in situations where susceptible
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COMMENTARIES
1039
subjects are brought together in close contact,such as in high schools, colleges, and military installations.
The timing of iinmunization is #{149}of critical
importance in reducing the susceptible popula-tion. Immunization must i)e carried out at an age
when it is most likely to be successful and at a
time when children are most likely to be seen by the pediatrician. The slightly higher rate of
successful immunization that niay be achieved by
immunizing older children imist be balanced
against the possibility that children may be
infected l)efore immunization or that they may be
less likely to return at a later date than an earlier one for immunization. The Committee on
Infec-tious Diseases of the American Academy of
Pedi-atrics (Red Book Coiniiiittee) has stated that “the
recoin mended age for measles
mi
iminization tinder usual circumstances is at or after 15 months of age. “ ‘ This recommendation has been ques-tioned by many in this country and abroad. Ourneighbors to the north, for instance, have elected to continue to inimunize Canadian children
against measles at 12 months of age.
New recommendations for measles
immuniza-tion were issued in June 1977 following the
largest epidemic of measles we had experienced
in this country since 1971. In examining these
data, however, it was clear that school-aged
children were those most affected. Sixty-five
percent of the reported cases, moreover, occurred
in children 10 years of age or older. During the
epidemic, there was but a minimal increase in cases in preschool children. What was most
disconcerting was the observation that many of the school-aged children had a history of previous
inmunization. It was found that a large
propor-tion of those previously immunized in whom measles developed had received vaccine before their first birthday. There was some suggestion,
moreover, that those immunized at 12 or 13
months were less well protected than those immunized later.’ It is iniportant to reemphasize
that the high attack rate in school-aged children
compared to that in younger children does not
indicate loss of vaccine-induced immunity. There was no relationship, for instance, between time since immunization and vaccine failure rate.’
It is clear from the experience during the 1977
epidemic that there was a problem at the time school-aged children received their vaccine that resulted in a surprising nunhl)er of vaccine fail-tires. In addition to age at immunization, other
factors (e.g., the use of immune serum globulin with further attenuated vaccine, improper
stor-age of vaccine, and administration of killed vaccine before administration of live vaccine) ulay have contributed to the disappointing performance of measles vaccine given at that
time. It must l)e reeiiiphasized, however, that
during the 1977 epidemic preschool children appeared to be well protected. One must raise the question, therefore, as to whether the prob-lem or problems that existed at the time the 10- to 14-year-old group was immunized stopped being a probleni five years ago.’ In comparing
hemag-glutinatioii inhibition titers of vaccines, Yeager et
al.’ reported a higher failure rate in 1 1-, 12-, 13-, or 14-month old children immunized between
1969 and 1976 than in those immunized since that
time. They found, moreover, that the measles antibody titer in cord ser#{227}of children in 1976 was
approximately half of what it was in 1969 to 1970.
They suggest that higher maternal antibody titers in those earlier years may have persisted longer,
e.g., beyond the first birthday. The presence of
maternal antibody in these infants may have neutralized measles vaccine virus and prevented successful immunization of babies during this
earlier period. If this is indeed the case, the
change in recommended date for immunization
from 12 to 15 months at this time may be
irrational and perhaps counterproductive.
In delaying immtinization to 15 months, it is expected that a gain in the nuniber of infants
successfully immunized will more than offset the effects of postponement. The AAP Committee on
Standards of Child Health Care does not, at the
present time, recommend a scheduled visit to the pediatrician at 15 months of age. If parents are less likely to bring their children back for health care during the second year of life than during the
first, fewer children may be immunized. Because measles vaccine is usually given in combination with rubella and mumps vaccines, a number of
children may be unprotected not only against
measles but niumps and rubella as well. This
would be of particular concern among those groups who have a record of poor compliance. In 1975, when immunization was recommended at
the first birthday, it was estimated that only 53.9% of nonwhite children and 68% of white children ages 1 to 4 had received measles vaccine.
Rather than return at 15 months of age, chil-dren may l)e brought for immunization at 18
months of age. If an epidemic should occur, the very vulnerable young group would I)e
unpro-tected. During the 1977 epideinic in San Antonio,
Texas, a substantial number of the cases of
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1040 MEASLES IMMUNIZATION
measles in unininuinized individuals occurred in
this very young age group. Although the new
recommendations state that “in the face of a measles outl)reak, infants at risk of exposure may
he imnmnized as early as 6 months,” there were
no guidelines to define whether or not there was an outbreak. As there was great geographic
van-ation in the incidence of measles, each
communi-ty had to decide on its own whether to implement the recommendation to immunize at 6 months. The lack of guidelines resulted in a delay in
implementation with increased morbidity in the very young. In the case of polio, it was deemed
that two cases of the same senotpe within a 30-day period constitute sufficient evidence to
insti tute coii munity ml niunization programs. Similar guidelines are required for measles.
In trying to assess the advantage of changing
the immunization date from 12 to 15 months, we must be able to quantitate the advantage of such a change. Statistical difference assures us of the reliability of our data. They do not provide us
with the numerical difference which must be
weighed against the disadvantages of delaying
immunization to 15 months. The Red Book
Committee obviously considered the quantitative factor in making the additional recommendation
that
children whose live measles vaccine was given at or shortly after 12 months but before 15 months (during an epidemic) need not be recalled for immunization. However, such children should not be denied vaccine if they are brought for
this purpose to a physicians office or other health facility.
The assessment of vaccine efficacy must be based on what actually happens to children when
they are exposed to measles rather than solely on
serologic testing. Laboratory tests merely provide a guide for what one might expect in a clinical
situation. Indeed, Shasby et al. report that “at-j though the prevalence of detectable antibody in
children vaccinated at 13 months is greater than that in those vaccinated at 12 months, the difference was not quite significant in the attack
rates between these groups.” ‘ What is even more impressive is the failure of Marks et al.7 to find clinically significant differences between attack rates in children immunized at 12, 13, 14, or 15 months. Yeager et at. have-been careful to identify the variables of the hemagglutination inhibition test within their laboratory that may affect
results. Undoubtedly, some of the differences
between investigators reflect differences in sero-logic testing between laboratories. It is clear, moreover, that more recent investigations have failed to confirm that greater seroconversion rates are achieved when children receive measles
vaccine at 15 rather than 12 months of age.8-9
It is important to put things in perspective with
respect to measles vaccine. We now talk of cases in terms of tens rather than hundred thousands of
cases per annum and deaths in dozens rather than hundreds per annum. The attack rate for children aged 1 to 4 was 35/
100,000
in 1977, an epidemicyear, compared to 3,380/ 100,000 in the years 1960 to 1964 prior to measles vaccine. In the 10-to 14-year-old group, about whom we are most
concerned, the attack rates during comparable periods are 845 and 105, respectively. We still
must address the problem of high school- and college-age youths and military recruits. Several possibilities must be explored, including the option to permit nature to take its course, i.e., permit the pool of susceptible subjects to become exhausted by natural infection. It has been
suggested that serologic screening be carried out but there is no simple, inexpensive way for mass screening by hemagglutination inhibition at the present time. We are all aware of the inaccuracy of relying on history of illness or immunization to determine the need for immunization. The
suggestion that immunization routinely be given twice, once during and once after infancy, also must be examined.
The continuing presence of measles as a prob-tern 15 years after the introduction of vaccine
causes us to focus on some of the unanswered questions. Where, for instance, is the virus
between epidemics? Neutralization of vaccine
virus by passively acquired maternal antibody
cannot explain all of the vaccine failures early in the second year of life.8 Is there still something we do not hilly comprehend about the relative
inabil-ity of children of this age to respond to measles or
bacterial polysaccharide antigens? Most
impor-tant, how are we to achieve greater compliance
with immunization programs?
The enforcement of laws that require measles
immunization for school attendance has clearly
had an impact on reducing measles incidence.0
Hopefully, the increased use of television to
encourage immunization of younger children will also be effective. If we are to achieve our goal of reducing morbidity produced by natural infection and eradicating disease, advances in administer-ing vaccines must keep pace with our ability to develop these products.
PHILIP A. BRUNELL, M.D.
Department of Pediatrics,
The University of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio, TX 78284
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PEDIATRICS
Vol. 62 No. 6
December 1978 1041 REFERENCES1. Committee on Infectious Diseases: Measles- Vaccine
Recommendations-. Evanston, Ill, American Acade-my of Pediatrics, June 1977.
2. Measles-United States, 1977-1978. Morbidity Mortality Weekly Rep 27:235, July 14, 1978.
:3. Shelton JD, Jacobson JF, Orenstein WA, Schulz KF:
Measles vaccine efficacy: The influence of age at vaccination versus duration of time since
vaccina-tion.Pediatrics 62:961, 1978.
4. Shasby DM, Shope TC, Downs H, et al: Epidemic measles in a highly vaccinated population. N Engl I Med 296:585, 1977.
5. Yeager AS, Davis JH, Ross LA, et al: Measles immuni-zation: Successes and failures. JAMA 237:347, 1977.
6. Measles Surveillance, Report No. 10, 1973-1976. Atlan-ta, Center for Disease Control, 1977, p 16. 7. Marks JS, Halpin TJ, Orenstein WA: measles vaccine
efficacy in children previously vaccinated at 12 months of age. Pediatrics 62:955, 1978.
8. Wilkins J, Wehrle PF: Evidence for reinstatement of infants 12 to 14 months of age into routine measles
immunization programs. Am I Dis Child 132:164, 1978.
9. Reynolds DW, Stagno 5, Herrman KL, et al: Antibody
response to live virus vaccines in congenital and
neonatal cytomegalovinis infections. I Pediatr 92:738, 1978.
10. Measles and school immunization requirements-United States, 1978. Morbidity Mortality Weekly Rep 27:303, August 18, 1978.
Asthma
and
allergists:
A modern
perspective
In the current issue of Pediatrics (page 1061), Leffert elegantly reviews the theories of asthma pathogenesis, while identifying areas of our continued ignorance. He also calls for pediatri-cians to assume a more central role in the
management of this condition rather than resort
to the traditional, often near automatic practice of referring and deferring to allergists. It would be a pity to obscure the important theme of Leffert’s article by an intramural fight for “turf” between pediatricians and allergists.
The noteworthy points of Leffert’s article are: (1) Not all asthma is due to allergy. (2) Dramatic developments in asthma therapy have taken place in recent years. ‘ “ (3) Means for satisfactory control of asthma in the vast majority of asthmat-ics is at hand.
The long-standing assumption that all
asthmat-ics can be presumed to have a significant “allergic
component” has resulted in (1) a relative neglect
of the study of nonallergic asthma mechanisms;
(2) a relative lack of appreciation of the hetero-geneity of asthma or “the asthmas”5; (3) a relative
distraction from application of pharmacologic
therapy with understanding, precision, and meticulous attention to detail; and (4) a relative
overuse of allergy injection therapy for asthma in terms of both duration of therapy and numbers of patients who receive it.’
Pediatricians who believe that skepticism of allergists and their practices is evidence of critical
acumen should not be reassured by Leffert’s
message. It would be harmful to conclude that
allergy consultations for asthmatics are not neces-sary. If pediatricians were to continue to manage
asthma medically by the precepts taught in medi-cal schools and training programs just a few years ago, they would not be giving adequate care today. Pediatricians can and should assume a greater role in asthma management, but they can do so only if they are willing to (1) update their understanding of the mechanisms of asthma; (2) update their knowledge of the now more compli-cated pharmacologic treatment of asthma; (3) give up some old misconceptions concerning asthma; (4) devote the time necessary to teach the patient and/or parents what they need to know about the condition; (5) devote the time necessary to secure compliance with a chronic or intermit-tent medication program; and (6) devote the time
during follow-up to adjust and readjust the medi-cation program to the patient’s individual need and tolerance.
Pediatricians can further improve their service to asthmatics by understanding the proper role of the modern allergist. A modern allergist should be expected to contribute to an asthmatic’s care in
any or all of the following specific areas: (1) aid in
the diagnosis of asthma, not by skin testing but by
objective demonstration of reversibility of airway
obstruction; (2) provide objective assessment of control by means of serial pulmonary function
measurements; (3) determine whether a
signifi-cant allergic cause plays a role; (4) identify the predominant allergic cause if such is present; (5) define whether the predominant allergic cause is avoidable, and give specific, individualized advice (not the standard “dust control” handouts) for avoidance based on identification of specific cause; (6) refine pharmacologic management with
emphasis on reducing medication side effects and minimizing the use of steroids; (7) devote time to those patients whose severity of condition, personal attitudes, and prior misconceptions require extraordinary attention; (8) identify and manage underlying complications; (9) define
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1978;62;1038
Pediatrics
Philip A. Brunell
Measles immunization: 12 or 15 months?
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1978;62;1038
Pediatrics
Philip A. Brunell
Measles immunization: 12 or 15 months?
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