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Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.

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Figure

Figure 1. Cytoskeletal networks in normal mammaryimages of F-actin (magenta), pS19-MLC2 (green) and DAPI (blue)
Figure 2. A Cdc42-defective binding mutant of Cdc42EP3 presents a diffuse pattern of cytosolic localization and does not induce actinand septin rearrangements in normal fibroblasts
Figure 3. A Cdc42-defective binding mutant of Cdc42EP3 acts as a dominant-negative when expressed in cancer-associated(CAFs)
Figure 4. Modulating the activity of Cdc42 in CAFs affects Cdc42EP3 localization and septin and F-actin organization
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