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Part 1 of 5 Abbott Laboratories Beckman Coulter BioMérieux

Deborah Anderson [email protected] Sudhish Subhash [email protected] Kesava Nagar-Anthal [email protected] 100 Abbott Park Rd., CP1-4, Abbott Park, IL 60064 250 S. Kraemer Blvd., Brea, CA 92821 100 Rodolphe St., Durham, NC 27712

See captodayonline.com/productguides for an interactive version of guide 847-936-6353 www.abbottdiagnostics.com 714-871-4848 www.beckmancoulter.com 919-620-3372 www.biomerieuxperformancesolutions.com Name of middleware system Instrument Manager (supplied by Data Innovations) Remisol Advance† (supplied by Normand-Info SAS) Myla

Products that middleware connects to LIS chemistry/hematology/immunology lab instruments, microbiology instruments, AP devices/instruments (to AP LIS), POC testing instruments, departmental or total lab automation systems, others

chemistry/hematology/immunology lab instruments, departmental or total lab automation systems, coagulation instruments, microscope, others

microbiology instruments, departmental or total lab automation systems

First ever middleware installation/Most recent installation* 2007/December 2012 1996/January 2013 2010/November 2011

Last update of middleware system December 2012 November 2012 November 2011

No. of contracts for sites operating middleware ~2,500 300+

• U.S. contracts/Foreign contracts (countries) — (Canada, Europe, Australia, New Zealand, others) — (Canada, France, Germany, Switzerland, others)

• No. of these contracts signed in calendar-year 2012 100+

No. of sites operating middleware/Percent of business that is middleware 100+/— 300+/—

No. of employees in firm/In middleware development, install, support ~35,000/— ~11,000/— ~6,400/80+

Provide list of client sites to potential customers on request yes (based on the customer’s criteria) yes (a list of selected reference sites only) yes (a list of selected reference sites only)

Hardware platforms Windows PC, server Dell HP ML350 G6 server

• Proprietary hardware required no yes (for all versions of middleware) yes (for all versions of middleware)

Software platforms Windows 2000 Professional, XP, 2000 server, 2003

server, 2008 server, Vista, Windows 7 Professional Windows server 2008 R2 Windows server 2008

Fault-tolerant solutions/Hardware must be purchased from company yes/no yes/yes yes/yes

Middleware software or drivers can operate in virtual hardware environment yes no no

Databases used or supported InterSystems Caché Microsoft SQL Server 2008 PostgreSQL

No. of results/orders that can be stored in database unlimited/unlimited 9,000,000/9,000 up to 10 years worth/—

Middleware can interface with instruments from any manufacturer yes no (with Roche, Abbott, Siemens, others) no (with BioMérieux)

Types of data middleware can receive, store, transmit alpha numeric, image alpha numeric, image alpha numeric, image

No. of instruments one middleware device can support 25 depends on IT configuration; could be unlimited

Protocols middleware supports to interface to instruments HL7, ANSI, XML, ASTM, proprietary, others ASTM, proprietary XML, ASTM, proprietary, BCI Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP, FTP, LAT serial RS232, TCP/IP, FTP, FXP serial RS232, TCP/IP

Middleware can send results to and receive orders from reference labs yes yes yes

LIS/HIS/EMR interfaces for receiving orders Sunquest, Meditech, Healthvision, Cerner, Allscripts,

GE Healthcare, SCC Soft Computer, others Meditech, McKesson, Sunquest, SCC Soft Computer, Cerner, other systems that support ASTM Sunquest, Cerner, Meditech, Orchard, Siemens, Technidata, Telepath, others LIS/HIS/EMR interfaces for sending results Sunquest, Meditech, Healthvision, Cerner, Allscripts,

GE Healthcare, SCC Soft Computer, others Meditech, McKesson, Sunquest, SCC Soft Computer, Cerner, other systems that support ASTM Sunquest, Cerner, Meditech, Orchard, Siemens, Technidata, Telepath, others

No. of diff. host system connections that can operate at once on middleware unlimited 2 5

Protocols middleware supports to interface to other systems HL7, ANSI, XML, ASTM, proprietary, ODBC ASTM, proprietary, FTP, FXP XML, ASTM, BCI Middleware can be configured to automatically forward reportable diseases

and other data to public health surveillance systems no no no

Human languages (other than English) middleware supports most languages French, German Chinese, French, Italian, German, many others

• Multiple languages can be used at same time on one system yes no yes

Middleware supports local date and time formats yes yes yes

No. of users that can access middleware at once unlimited 255 unlimited

No. of user security levels middleware supports unlimited 3 4

Middleware supports compound nested rules with multiple event actions yes yes yes

• Multiple event actions fired from one “if” condition statement yes yes no

Programming or script language required to write rules no no no

Full and persistent audit trail of rule execution/System supports rules testing yes/yes yes/yes no/no

Rule sets applied to individual instruments or connections yes yes yes

Data from external databases retrieved and incorporated in rules processing yes no no

Rules test cases created, saved, used on demand for rules validation testing yes yes no

System supports event notification yes yes yes

System user notified of rules-based events/Notification methods supported yes/pop-up windows, e-mail, pager, audio/visual device yes/scrolling event log, pop-up windows, filtered

window views, color and flag codes yes/flashing screen, e-mail, SMS, light pole

Automation routes determined by user-defined rules yes yes no

Middleware supports test-based load balancing across instruments yes yes no

Events that lead to automation routes being dynamically updated new test requests, reflex test requests, instrument down none

Audit trail of route a sample has taken yes yes yes

Laboratory automation system interfaces Abbott, A&T Corp. Beckman Coulter, Olympus America none

Middleware interfaces with noninstrument automation devices yes yes no

Back-end specimen storage and retrieval tracking yes yes no

System allows management of inst. & automation device maintenance records yes yes no

• System provides alerts when an instrument needs maintenance yes no yes

System provides LIS downtime functions/System allows manual order entry yes/yes yes/yes no/no

System generates downtime specimen ID/Algorithm for ID user definable yes/yes yes/yes no/no

Quality control module/Interfaces to third-party quality control packages yes/yes (Bio-Rad Unity Real Time, others) yes/yes (Bio-Rad, Thermo Fisher) no/no

System supports multi-rule quality control yes yes no

System supports moving averages or average of normals yes yes no

Users can customize screens/Users can define custom fields yes/yes yes/yes yes/yes

Users can populate custom fields via user-defined rules yes yes no

Screen has image support for any type of image yes no no

Users can design own reports/Report-generation software used yes/ODBC compliant yes/proprietary no/—

LOINC can be used to ID tests when communicating with LIS yes yes no

Methods by which users can tailor middleware in their own setting dictionary settings dictionary settings

Types of system training available/On-site consulting classroom, on-site/yes classroom, on-site, e-learning, user groups/yes on-site, e-learning/yes

Smallest cost for hardware/software/annual maintenance

Largest cost for hardware/software/annual maintenance

Fee for additional users

Cost for cloud-based or similar products/services

Distinguishing features of middleware (supplied by company)

*based on January 2013 survey deadline

Note: a dash in lieu of an answer means company did not answer question or question is not applicable

• a foundational rule set that can scale to complex, customizable rule development • scalability through connectivity to multi-departments, multi-sites, multi-LISs, more • autoverification, moving averages, other consulting

services via implementation and support team

• integrated extended QC module monitors system operation using patient moving average data, more • alerts operator of critical test results; lab’s key

operators can develop, maintain complex rules • on-site customization/implementation services formerly Beckman Coulter DL2000

• unique dashboard style; real-time, icon-driven, customizable user interface; integrated middleware specifically for microbiology laboratories; provides real-time quality indicators to monitor key microbiology testing processes

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Part 2 of 5 Common Cents Systems Data Innovations Dawning Technologies Carl Barringer [email protected] Sales Department [email protected] Jay Sax [email protected]

4701 Trousdale Drive, Suite 119, Nashville, TN 37222 120 Kimball Ave., Suite 100, South Burlington, VT 05403 8140 College Parkway, Suite 202, Fort Myers, FL 33919 See captodayonline.com/productguides for an interactive version of guide 800-805-9278 www.apollolims.com 802-658-2850 www.datainnovations.com 239-931-6004 www.dawning.com

Name of middleware system Apollo Instrument Manager† Instrument Manager JavaLin Interfaces

Products that middleware connects to LIS chemistry/hematology/immunology lab instruments, microbiology instruments, AP devices/instruments (to AP LIS), POC testing instruments, departmental or total lab automation systems

chemistry/hematology/immunology lab instruments, microbiology instruments, AP devices/instruments (to AP LIS), POC testing instruments, departmental or total lab automation systems, others

chemistry/hematology/immunology lab instruments, microbiology instruments, POC testing instruments, departmental or total lab automation systems

First ever middleware installation/Most recent installation* 2001/December 2012 1993/February 2013 1984/January 2013

Last update of middleware system January 2012 March 2013 October 2012

No. of contracts for sites operating middleware 38 3,782 3,400

• U.S. contracts/Foreign contracts (countries) 37/1 (Trinidad and Tobego) 3,007/775 (in 74 countries) 2,950/450 (in 30+ countries)

• No. of these contracts signed in calendar-year 2012 5 356 300

No. of sites operating middleware/Percent of business that is middleware 38/75% 4,213/100% 3,600/100%

No. of employees in firm/In middleware development, install, support 11/9 100/47 25/20

Provide list of client sites to potential customers on request yes (a list of all comparable laboratory sites) yes (list of comparable sites, with client approval) yes (a list of all comparable laboratory sites)

Hardware platforms Windows PC, Windows server Windows PC, servers, virtualized servers Dawning JavaLin/PDI

• Proprietary hardware required no no yes (for all versions of middleware)

Software platforms Microsoft Windows XP, 7, Windows servers Windows XP, 2003 server, 2008 server (32 bit and 64

bit), Vista, Windows 7 (32 and 64 bit operating systems) Linux OS, Java-based embedded Dawning JResultNet

Fault-tolerant solutions/Hardware must be purchased from company yes/no yes/no yes/yes

Middleware software or drivers can operate in virtual hardware environment yes yes yes

Databases used or supported InterSystems Caché, Microsoft SQL InterSystems Caché HSQL, Codebase

No. of results/orders that can be stored in database limited only by storage capacity/limited only by

storage capacity limited only by storage capacity/limited only by storage capacity 1,000+/1,000+

Middleware can interface with instruments from any manufacturer yes yes yes

Types of data middleware can receive, store, transmit alpha numeric, image, sound alpha numeric, image, TXT reports, PDF, others alpha numeric

No. of instruments one middleware device can support limited only by storage and processing capacity unlimited 2

Protocols middleware supports to interface to instruments HL7, XML, ASTM, flat file, CSV multiple HL7, ANSI SQL, XML, ASTM, proprietary,

Web services, file import/export, ODBC, others HL7 (all versions below 3.0), ANSI, XML, ASTM, proprietary, CSV, flat file, direct database, others Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP, FTP, LAT serial RS232, serial USB, TCP/IP, FTP, ODBC, others serial RS232, serial USB, TCP/IP, FTP, flat file Middleware can send results to and receive orders from reference labs yes (Quest, LabCorp) yes (Quest, LabCorp, ARUP, Mayo Clinic, others) yes (LabCorp, Quest, Specialty Laboratories, AML) LIS/HIS/EMR interfaces for receiving orders Sunquest, GE Healthcare, Siemens, NextGen,

eClinicalWorks, RioMed Epic, McKesson, Cerner, Siemens, Sunquest, Meditech, GE, Wyndgate, Healthland, others Cerner, CPSI, Custom Software Solutions, McKesson, GE Healthcare, Psyche, Siemens, Epic, others LIS/HIS/EMR interfaces for sending results Sunquest, GE Healthcare, Siemens, NextGen,

eClinicalWorks, RioMed Epic, McKesson, Cerner, Siemens, Sunquest, Meditech, GE, Wyndgate, Healthland, others Cerner, CPSI, Custom Software Solutions, McKesson, GE Healthcare, Psyche, Siemens, Epic, others

No. of diff. host system connections that can operate at once on middleware unlimited unlimited unlimited

Protocols middleware supports to interface to instruments multiple HL7, ANSI 1238, 1394, XML, ASTM, others multiple HL7, ANSI ODBC/SQL, XML, ASTM, others HL7, ANSI, XML, ASTM, proprietary, CSV, others Middleware can be configured to automatically forward reportable diseases

and other data to public health surveillance systems yes—to state and county public health labs yes no

Human languages (other than English) middleware supports none all known languages German, French, Spanish, Portuguese, others

• Multiple languages can be used at same time on one system no yes yes

Middleware supports local date and time formats no yes yes

No. of users that can access middleware at once unlimited (based on No. of user licenses) unlimited unlimited

No. of user security levels middleware supports unlimited unlimited (user defined) unlimited

Middleware supports compound nested rules with multiple event actions yes yes yes

• Multiple event actions fired from one “if” condition statement yes yes yes

Programming or script language required to write rules no no no

Full and persistent audit trail of rule execution/System supports rules testing yes/yes yes/yes yes/yes

Rule sets applied to individual instruments or connections yes yes yes

Data from external databases retrieved and incorporated in rules processing yes yes yes

Rules test cases created, saved, used on demand for rules validation testing yes yes yes

System supports event notification yes yes yes

System user notified of rules-based events/Notification methods supported yes/pop-up, pager, e-mail, color coding of data yes/pop-up windows, e-mail, pager, others yes/pop-up windows, e-mail, audio alert, others

Automation routes determined by user-defined rules yes yes yes

Middleware supports test-based load balancing across instruments no yes yes

Events that lead to automation routes being dynamically updated none new test requests, reflex test requests, instrument

down, deletion or revision of test requests and results new test requests, reflex test requests, instrument down

Audit trail of route a sample has taken yes yes yes

Laboratory automation system interfaces Roche Beckman, Ortho, Abbott, Roche, Sysmex, others Ortho, Abbott, Roche, Olympus, Siemens, others

Middleware interfaces with noninstrument automation devices yes yes yes

Back-end specimen storage and retrieval tracking yes yes no

System allows management of inst. & automation device maintenance records no yes no

• System provides alerts when an instrument needs maintenance no yes no

System provides LIS downtime functions/System allows manual order entry yes/yes yes/yes yes/yes

System generates downtime specimen ID/Algorithm for ID user definable yes/yes yes/yes yes/yes

Quality control module/Interfaces to third-party quality control packages yes/no yes/yes (Bio-Rad, Thermo Scientific, others) yes/yes (Bio-Rad)

System supports multi-rule quality control yes yes yes

System supports moving averages or average of normals yes yes no

Users can customize screens/Users can define custom fields yes/yes yes/yes yes/yes

Users can populate custom fields via user-defined rules yes yes yes

Screen has image support for any type of image no yes no

Users can design own reports/Report-generation software used yes/integrated ad hoc report writer, others yes/any ODBC compliant, internal proprietary yes/Crystal Reports

LOINC can be used to ID tests when communicating with LIS yes yes

Methods by which users can tailor middleware in their own setting scripting, ad hoc query tools scripting, ad hoc query tools, others ad hoc query tools, dictionary settings, others Types of system training available/On-site consulting on-site training, Web training, classroom/yes classroom, on-site, e-learning, Web based/yes classroom, on-site, Web based/yes

Smallest cost for hardware/software/annual maintenance —/$3,095/$557.10 $2,200/included/$225

Largest cost for hardware/software/annual maintenance —/$897,000/$161,460 $5,800/$4,500/$1,185

Fee for additional users $1,650 none

Cost for cloud-based or similar products/services

Distinguishing features of middleware (supplied by company)

*based on January 2013 survey deadline

Note: a dash in lieu of an answer means company did not answer question or question is not applicable

• integration of pre-analytical, analytical, and post- analytical information into the processing of results • multi-site, multi-host, multi-laboratory capability • on-site or cloud-based implementation model formerly Common Cents’ Cirrus Instrument Manager

• workflow solutions for multiple lab disciplines affecting areas beyond results production • affordable for small clinics, yet scalable for large labs • intuitive solutions and comprehensive services to

support clients and augment available resources

• distributed processing in a 3-in. × 5-in. footprint • can add a new instrument on a single connection

to the LIS using any standard protocol without disturbing existing connections

(3)

Part 3 of 5 Dawning Technologies HealthBlocks Pathagility

Jay Sax [email protected] Justin Langhorst [email protected] Mark McCuin [email protected]

8140 College Parkway, Suite 202, Fort Myers, FL 33919 807 Green Tree Court, Duncanville, TX 75137 10810 Executive Center Drive, Suite 100, Little Rock, AR 72211 See captodayonline.com/productguides for an interactive version of guide 239-931-6004 www.dawning.com 972-836-7992 www.healthblocks.com 888-222-2792 www.pathagility.com

Name of middleware system JResultNet Middleware ENQ AgilityEngine

Products that middleware connects to LIS chemistry/hematology/immunology lab instruments, microbiology instruments, POC testing instruments, departmental or total lab automation systems

chemistry/hematology/immunology lab instruments, microbiology instruments, AP devices/instruments (to AP LIS), POC testing instruments, departmental or total lab automation systems, others

chemistry/hematology/immunology lab instruments, microbiology instruments, AP devices/instruments (to AP LIS), POC testing instruments, molecular/ genomic testing devices

First ever middleware installation/Most recent installation* 1984/January 2013 2004/December 2012 2008/December 2012

Last update of middleware system July 2012 December 2012 December 2012

No. of contracts for sites operating middleware 2,000 80 8

• U.S. contracts/Foreign contracts (countries) 1,700/300 (in 30+ countries) 65/15 (Australia, France, Germany, Chile, others) 8/0

• No. of these contracts signed in calendar-year 2012 200 15 3

No. of sites operating middleware/Percent of business that is middleware 2,500/100% 85/100% 15/20%

No. of employees in firm/In middleware development, install, support 25/20 8/5 —/4

Provide list of client sites to potential customers on request yes (a list of all comparable laboratory sites) no (confidential) yes (a list of all comparable laboratory sites)

Hardware platforms platform portable, PCs, Macs, servers, others PCs, enterprise-level servers hardware agnostic

• Proprietary hardware required yes (for some versions of middleware) yes (for some versions of middleware) no

Software platforms Windows 7, 2000, XP Professional, Linux, OS X, others Debian GNU/Linux Python, Windows, Mac, BSD, Solaris, others

Fault-tolerant solutions/Hardware must be purchased from company yes/no yes/no yes/no

Middleware software or drivers can operate in virtual hardware environment yes yes yes

Databases used or supported PostgreSQL, HSQL, Codebase, Microsoft SQL, others Microsoft, Oracle, Sybase, Informix, MySQL, others agnostic—MySQL, PostgreSQL, SQLite, Oracle No. of results/orders that can be stored in database 1,000+/1,000+ limited only by storage capacity/limited only by

storage capacity unlimited/unlimited

Middleware can interface with instruments from any manufacturer yes yes yes

Types of data middleware can receive, store, transmit alpha numeric alpha numeric, image, sound, any binary alpha numeric, image, sound, any file attachment

No. of instruments one middleware device can support unlimited 4-5 physical connections, hundreds on network

Protocols middleware supports to interface to instruments HL7 (all versions below 3.0), ANSI, ASTM, others HL7 2.x, 3.x, XML, ASTM, proprietary, HPRIM, CSV, BCI HL7 2.x, 3.x, ANSI, XML, ASTM, proprietary, custom Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP, FTP, ODBC, flat file serial RS232, serial USB, TCP/IP, FTP, LAT, NFS, others serial RS232, serial USB, TCP/IP, FTP, LAT, others Middleware can send results to and receive orders from reference labs yes (LabCorp, Quest, Specialty Laboratories, AML) no yes

LIS/HIS/EMR interfaces for receiving orders Cerner, CPSI, Custom Software Solutions, McKesson,

GE Healthcare, Psyche, Siemens, Epic, others Cerner, GE Healthcare, Meditech, Allscripts, Sunquest, McKesson, others Sunquest, Small Business Computers of New England, eMDs, Allscripts, eClinicalWorks, proprietary, others LIS/HIS/EMR interfaces for sending results Cerner, CPSI, Custom Software Solutions, McKesson,

GE Healthcare, Psyche, Siemens, Epic, others Cerner, GE Healthcare, Meditech, Allscripts, Sunquest McKesson, others Sunquest, Small Business Computers of New England, eMDs, Allscripts, eClinicalWorks, proprietary, others

No. of diff. host system connections that can operate at once on middleware unlimited hundreds unlimited

Protocols middleware supports to interface to instruments HL7, ANSI, XML, ASTM, proprietary, CSV, others HL7 2.x, 3.x, XML, ASTM, proprietary, HPRIM, CSV, BCI HL7 2.x, 3.x, ANSI, XML, ASTM, proprietary, custom Middleware can be configured to automatically forward reportable diseases

and other data to public health surveillance systems no yes yes

Human languages (other than English) middleware supports German, French, Spanish, Portuguese, others none none

• Multiple languages can be used at same time on one system yes no no

Middleware supports local date and time formats yes yes no

No. of users that can access middleware at once unlimited 100 unlimited

No. of user security levels middleware supports unlimited 1 ~5

Middleware supports compound nested rules with multiple event actions yes yes yes

• Multiple event actions fired from one “if” condition statement yes yes yes

Programming or script language required to write rules no yes no

Full and persistent audit trail of rule execution/System supports rules testing yes/yes yes/yes yes/yes

Rule sets applied to individual instruments or connections yes yes yes

Data from external databases retrieved and incorporated in rules processing yes yes yes

Rules test cases created, saved, used on demand for rules validation testing yes yes no

System supports event notification yes yes yes

System user notified of rules-based events/Notification methods supported yes/pop-up windows, e-mail, audio alert, others yes/e-mail yes/SMS, e-mail

Automation routes determined by user-defined rules yes no no

Middleware supports test-based load balancing across instruments yes yes no

Events that lead to automation routes being dynamically updated new test requests, reflex test requests, instr. down new test requests, reflex test requests, others none

Audit trail of route a sample has taken yes yes no

Laboratory automation system interfaces Beckman, Ortho, Abbott, Roche, Olympus, others Thermo Scientific

Middleware interfaces with noninstrument automation devices yes yes no

Back-end specimen storage and retrieval tracking no yes no

System allows management of inst. & automation device maintenance records yes no no

• System provides alerts when an instrument needs maintenance no no no

System provides LIS downtime functions/System allows manual order entry yes/yes no/no no/yes

System generates downtime specimen ID/Algorithm for ID user definable yes/yes no/no no/no

Quality control module/Interfaces to third-party quality control packages yes/yes (Bio-Rad) no/no no/no

System supports multi-rule quality control yes no no

System supports moving averages or average of normals no no no

Users can customize screens/Users can define custom fields yes/yes no/no no/no

Users can populate custom fields via user-defined rules yes no no

Screen has image support for any type of image no no yes

Users can design own reports/Report-generation software used yes/Crystal Reports no/— no/—

LOINC can be used to ID tests when communicating with LIS yes yes yes

Methods by which users can tailor middleware in their own setting ad hoc query tools, dictionary settings, others wraparound programming, dictionary settings wraparound programming, scripting, others

Types of system training available/On-site consulting classroom, on-site, Web based/yes e-learning/yes on-site, Web conferencing/yes

Smallest cost for hardware/software/annual maintenance —/$1,900/$230 —/$6,000/$1,250

Largest cost for hardware/software/annual maintenance —/depends on number of interfaces/depends on

number of interfaces $1,000/$6,000 × No. of bi-directional connections/ $1,250 × No. of bi-directional connections

Fee for additional users none none

Cost for cloud-based or similar products/services $2,500+ start-up cost/$5,000+ annual maintenance

or usage fee/$500+ monthly subscription fee Distinguishing features of middleware (supplied by company)

*based on January 2013 survey deadline

Note: a dash in lieu of an answer means company did not answer question or question is not applicable

• scalable solutions, from single instrument to enterprise-level middleware

• comprehensive rules development kit

• increases autoverification and reduces turnaround time with rules and calculations libraries

• configured so it arrives at user’s door ready to connect and integrate

• rapid development of message formats and protocols can be done on request • solves complex integration problems

• adds flexibility to the client’s system environment via its architecture and multiple deployment options • on-demand deployment

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Part 4 of 5 Roche Siemens Healthcare Diagnostics Siemens Healthcare Diagnostics

Aime Chidester [email protected] Sharon Etzman [email protected] Sharon Etzman [email protected] 9115 Hague Rd., Indianapolis, IN 46208 1717 Deerfield Rd., Deerfield, IL 60015 1717 Deerfield Rd., Deerfield, IL 60015 See captodayonline.com/productguides for an interactive version of guide 317-521-4776 www.roche-diagnostics.us 847-236-7421 www.siemens.com/diagnostics 847-236-7421 www.siemens.com/diagnostics

Name of middleware system Roche Middleware Solutions CentraLink Syngo Lab Data Manager

Products that middleware connects to LIS chemistry/hematology/immunology lab instruments, POC testing instruments, departmental or total lab automation systems, others

chemistry/hematology/immunology lab instruments,

departmental or total lab automation systems chemistry/hematology/immunology lab instruments, departmental or total lab automation systems

First ever middleware installation/Most recent installation* 1998/January 2013 2001/January 2013 2001/January 2013

Last update of middleware system December 2012 December 2012 July 2011

No. of contracts for sites operating middleware 585 818 157

• U.S. contracts/Foreign contracts (countries) 585/0 309/509 (worldwide) 122/35 (France, Australia, Canada, Portugal, others)

• No. of these contracts signed in calendar-year 2012 52 66 138

No. of sites operating middleware/Percent of business that is middleware 585/— 818/<5% 157/<5%

No. of employees in firm/In middleware development, install, support 4,200 (centralized diagnostics)/55 51,000/400 51,000/400

Provide list of client sites to potential customers on request yes (a list of selected reference sites only) yes (a list of all comparable laboratory sites) yes (a list of selected reference sites only)

Hardware platforms Dell OptiPlex 7010, Dell PowerEdge T620 tower

chassis, Dell PowerEdge R620 rack mount, other Dell dedicated computing high-capacity server, dedicated computing standard-capacity server dedicated computing high-capacity server, dedicated computing standard-capacity server • Proprietary hardware required yes (for some versions of middleware) yes (for all versions of middleware) yes (for all versions of middleware)

Software platforms Windows 7, Windows server 2008 R2 (64 bit) Windows server 2003, Windows XP Windows server 2008

Fault-tolerant solutions/Hardware must be purchased from company yes/no yes/yes yes/yes

Middleware software or drivers can operate in virtual hardware environment yes no no

Databases used or supported InterSystems Caché OpenEdge Microsoft SQL server 2008 R2

No. of results/orders that can be stored in database limited only by storage/limited only by storage up to 40,000,000/960,000 23,040,000/7,000,000 Middleware can interface with instruments from any manufacturer no (with numerous manufacturers’ instruments) yes no (with Siemens)

Types of data middleware can receive, store, transmit alpha numeric, image, other binary alpha numeric, image alpha numeric

No. of instruments one middleware device can support up to 300 32 32

Protocols middleware supports to interface to instruments HL7, XML, ASTM, ODBC, SQL, http HL7 2.5, ANSI 1394, ASTM, proprietary ANSI LIS1A, LIS2A (old standard E1394-97), ASTM Low-level transport middleware supports to interface to instruments serial RS232, TCP/IP, FTP serial RS232, TCP/IP, FTP serial RS232, TCP/IP

Middleware can send results to and receive orders from reference labs no no no

LIS/HIS/EMR interfaces for receiving orders McKesson, Sunquest, Cerner, SCC Soft Computer,

Meditech, homegrown LIS, others Antek, Sunquest, Aspyra, Apex, GE, Cerner, McKesson, SCC Soft Computer, Meditech, others Siemens, Cerner, Meditech, Sunquest, SCC Soft Computer, others LIS/HIS/EMR interfaces for sending results McKesson, Sunquest, Cerner, SCC Soft Computer,

Meditech, homegrown LIS, others Antek, Sunquest, Aspyra, Apex, GE, Cerner, McKesson, SCC Soft Computer, Meditech, others Siemens, Cerner, Meditech, Sunquest, SCC Soft Computer, others

No. of diff. host system connections that can operate at once on middleware unlimited multiple 1

Protocols middleware supports to interface to instruments HL7, XML, ASTM HL7 2.5, ANSI 1394, ASTM, Technidata LMX 6.0 ANSI LIS1A, LIS2A (old standard E1394-97), ASTM Middleware can be configured to automatically forward reportable diseases

and other data to public health surveillance systems no no

Human languages (other than English) middleware supports none Spanish, French, Italian, German, Dutch French, Italian, German, Spanish

• Multiple languages can be used at same time on one system no yes no

Middleware supports local date and time formats no yes yes

No. of users that can access middleware at once unlimited 15 25

No. of user security levels middleware supports unlimited (user defined) 4 3

Middleware supports compound nested rules with multiple event actions yes yes yes

• Multiple event actions fired from one “if” condition statement yes yes yes

Programming or script language required to write rules no no yes

Full and persistent audit trail of rule execution/System supports rules testing yes/yes yes/yes yes/—

Rule sets applied to individual instruments or connections yes yes yes

Data from external databases retrieved and incorporated in rules processing yes no no

Rules test cases created, saved, used on demand for rules validation testing yes yes yes

System supports event notification yes yes yes

System user notified of rules-based events/Notification methods supported yes/pop-up, e-mail, audio/visual yes/pop-ups, color cues, log files yes/visual notifications

Automation routes determined by user-defined rules yes yes yes

Middleware supports test-based load balancing across instruments yes yes yes

Events that lead to automation routes being dynamically updated new test requests, reflex test requests, instrument

down new test requests, reflex test requests, instrument down, QC performance, reagent inventory, test priority new test requests, reflex test requests, instrument down

Audit trail of route a sample has taken yes yes yes

Laboratory automation system interfaces Roche Siemens Siemens

Middleware interfaces with noninstrument automation devices yes yes no

Back-end specimen storage and retrieval tracking yes yes no

System allows management of inst. & automation device maintenance records yes no no

• System provides alerts when an instrument needs maintenance yes no no

System provides LIS downtime functions/System allows manual order entry yes/yes yes/yes yes/yes

System generates downtime specimen ID/Algorithm for ID user definable yes/yes yes/yes no/no

Quality control module/Interfaces to third-party quality control packages no/yes (Bio-Rad, Thermo Fisher) yes/yes (Bio-Rad) yes/yes (Bio-Rad)

System supports multi-rule quality control yes yes yes

System supports moving averages or average of normals yes yes yes

Users can customize screens/Users can define custom fields yes/yes yes/yes no/no

Users can populate custom fields via user-defined rules yes yes no

Screen has image support for any type of image yes no no

Users can design own reports/Report-generation software used yes/any ODBC compliant yes/text, html yes/Jasper

LOINC can be used to ID tests when communicating with LIS yes yes no

Methods by which users can tailor middleware in their own setting dictionary settings, user-configurable workspaces,

customizable user security ad hoc query tools, dictionary settings, rules, site functions, filters ad hoc query tools Types of system training available/On-site consulting Web-based courses, classroom, others/yes on-site, e-learning/yes on-site, e-learning/yes

Smallest cost for hardware/software/annual maintenance

Largest cost for hardware/software/annual maintenance

Fee for additional users

Cost for cloud-based or similar products/services

Distinguishing features of middleware (supplied by company)

*based on January 2013 survey deadline

Note: a dash in lieu of an answer means company did not answer question or question is not applicable

• mature middleware vendor; over 15 years supplier partnership with Data Innovations • pre-fabricated rules package designed

specifically for Roche analyzers

• multi-faceted customer-to-customer information sharing on middleware best practices

• comprehensive result-management and autoverification rules and integrated QC package • highly customizable workflow scenarios • robust and mature multi-discipline data-management and networking solution

• integrated quality control monitoring with patient result management

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Part 5 of 5 Sysmex America Sysmex America Technidata America Medical Software

Tammy Kutz [email protected] Tammy Kutz [email protected] Yves Charron [email protected] 577 Aptakisic Rd., Lincolnshire, IL 60069 577 Aptakisic Rd., Lincolnshire, IL 60069 5795 De Gaspé Ave., Ste. 223, Montreal H2S 2X3 Canada See captodayonline.com/productguides for an interactive version of guide 847-996-4500 www.sysmex.com/informationsystems 847-996-4500 www.sysmex.com/informationsystems 514-270-7777 ext. 803 www.technidata-web.com/

Name of middleware system Sysmex WAM† WAM Select TD-Harmony

Products that middleware connects to LIS chemistry/hematology/immunology lab instruments, departmental or total lab automation systems, tube sorter, digital cell morphology systems

chemistry/hematology/immunology lab instruments chemistry/hematology/immunology lab instruments, microbiology instruments, AP devices/instruments (to AP LIS), POC testing instruments, departmental or total lab automation systems, genetics, biobanking

First ever middleware installation/Most recent installation* 2003/December 2012 2003/December 2012 1993/December 2012

Last update of middleware system August 2011 October 2011 December 2012

No. of contracts for sites operating middleware 223 13

• U.S. contracts/Foreign contracts (countries) 209/14 (Canada) 13/0 unknown/unknown (Canada, France, Spain, Italy, others)

• No. of these contracts signed in calendar-year 2012 23 11 2

No. of sites operating middleware/Percent of business that is middleware 776/20% 13/20% unknown/15%

No. of employees in firm/In middleware development, install, support 724/112 724/112 270/130

Provide list of client sites to potential customers on request yes (a list of selected reference sites only) yes (a list of selected reference sites only) yes (a list of selected reference sites only)

Hardware platforms Red Hat Linux Windows any that support Microsoft Windows

• Proprietary hardware required no yes (for all versions of middleware) no

Software platforms Compuware Uniface Microsoft Microsoft Windows, Linux, Unix

Fault-tolerant solutions/Hardware must be purchased from company yes/no no/yes yes/no

Middleware software or drivers can operate in virtual hardware environment yes no yes

Databases used or supported Oracle SQL SQL server 2012, Oracle v. 11

No. of results/orders that can be stored in database 2 years worth/2 years worth 90 days worth/90 days worth unlimited/unlimited

Middleware can interface with instruments from any manufacturer no (with Sysmex, Bio-Rad, CellaVision) no (with Sysmex hematology analyzers) yes

Types of data middleware can receive, store, transmit alpha numeric, image alpha numeric, image alpha numeric, image

No. of instruments one middleware device can support unlimited across multiple sites 2 4,000

Protocols middleware supports to interface to instruments HL7 2.4, ANSI E1394, proprietary ASTM, proprietary HL7, ANSI, XML, ASTM, proprietary, HPRIM Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP serial RS232, serial USB, TCP/IP serial RS232, serial USB, TCP/IP, FTP, LAT, file sharing

Middleware can send results to and receive orders from reference labs no no yes (Labquest, LabCorp, Dynacare, LifeLabs, Mayo)

LIS/HIS/EMR interfaces for receiving orders Epic, Sunquest, Cerner, Meditech, McKesson, Siemens,

QuadraMed, SCC Soft Computer, Diamond, others Sunquest, Meditech, CPSI, Orchard Meditech, Cerner, Keane, Stemsoft, Sunquest, others LIS/HIS/EMR interfaces for sending results Epic, Sunquest, Cerner, Meditech, McKesson, Siemens,

QuadraMed, SCC Soft Computer, Diamond, others Sunquest, Meditech, CPSI, Orchard Meditech, Cerner, Keane, Stemsoft, Sunquest, others

No. of diff. host system connections that can operate at once on middleware unlimited 1 4,000

Protocols middleware supports to interface to instruments HL7 2.4, ANSI E1394, ASTM, proprietary ASTM, proprietary HL7 2.x, ANSI, XML, ASTM, proprietary, HPRIM Middleware can be configured to automatically forward reportable diseases

and other data to public health surveillance systems no no yes (in United Kingdom and Canada)

Human languages (other than English) middleware supports none French, Spanish French, Spanish, Dutch, German, Italian, others

• Multiple languages can be used at same time on one system no no yes

Middleware supports local date and time formats yes no yes

No. of users that can access middleware at once unlimited 1 unlimited (but hardware dependent)

No. of user security levels middleware supports unlimited 2 unlimited

Middleware supports compound nested rules with multiple event actions yes yes yes

• Multiple event actions fired from one “if” condition statement yes yes yes

Programming or script language required to write rules no no no

Full and persistent audit trail of rule execution/System supports rules testing yes/yes yes/yes yes/yes

Rule sets applied to individual instruments or connections yes no yes

Data from external databases retrieved and incorporated in rules processing no no no

Rules test cases created, saved, used on demand for rules validation testing no yes no

System supports event notification yes yes yes

System user notified of rules-based events/Notification methods supported yes/pop-up, audio/visual yes/pop-up, audio/visual yes/e-mail, SMS, printout

Automation routes determined by user-defined rules yes no yes

Middleware supports test-based load balancing across instruments yes no yes

Events that lead to automation routes being dynamically updated new test requests, reflex test requests, instr. down none new test requests, reflex test requests, instr. down

Audit trail of route a sample has taken yes no yes

Laboratory automation system interfaces Sysmex Beckman, Roche, Ortho, Abbott, Olympus, others

Middleware interfaces with noninstrument automation devices yes no yes

Back-end specimen storage and retrieval tracking yes no yes

System allows management of inst. & automation device maintenance records no no yes

• System provides alerts when an instrument needs maintenance no no no

System provides LIS downtime functions/System allows manual order entry yes/yes no/no yes/yes

System generates downtime specimen ID/Algorithm for ID user definable no/yes no/yes yes/yes

Quality control module/Interfaces to third-party quality control packages yes/no no/no yes/yes (Bio-Rad)

System supports multi-rule quality control yes no yes

System supports moving averages or average of normals yes no yes

Users can customize screens/Users can define custom fields no/yes no/no yes/no

Users can populate custom fields via user-defined rules yes no no

Screen has image support for any type of image yes yes yes

Users can design own reports/Report-generation software used no/— no/— yes/proprietary, Crystal Reports

LOINC can be used to ID tests when communicating with LIS no no yes

Methods by which users can tailor middleware in their own setting dictionary settings dictionary settings wraparound programming, scripting, ad hoc query tools, user-defined interfaces, dictionary settings Types of system training available/On-site consulting classroom, virtual, on-site, e-learning/yes e-learning/yes e-learning, on-site, classroom (on demand)/yes

Smallest cost for hardware/software/annual maintenance $500/$4,000/$800

Largest cost for hardware/software/annual maintenance $40,000/$350,000/$70,000

Fee for additional users $2,000

Cost for cloud-based or similar products/services

Distinguishing features of middleware (supplied by company)

*based on January 2013 survey deadline

Note: a dash in lieu of an answer means company did not answer question or question is not applicable

• flexible rule engine with extensive rule-variable combinations for building rules for autovalidation, reflexing, add-on testing, specimen aging, more • management reports module provides real-time

data mining

• proactive alert-monitoring system formerly Sysmex Molis WAM

• hematology-specific rules that help labs achieve greater than 85 percent autovalidation rates • designed for small to medium-sized labs • allows users to easily and independently manage

decision rules in hematology

• ability to cover all clinical and anatomic pathology disciplines

• “push” information system

• new and painless way to go from a legacy LIS to a middleware solution and then to a new LIS

References

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