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Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

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Figure

Figure 1: Venn diagram highlighting the conserved upregulation of ribosomal-related proteins in both MCF7 and T47D mammospheres
Figure 3: Puromycin: Structure and key features. Puromycin resembles the 3’ end of an aminoacylated tRNA, which interacts with the A-site of the ribosome
Figure 6: Rapamycin significantly reduces mammosphere formation in MCF7 cells. Note that rapamycin also effectively reduces mammosphere formation in this cellular context, with an IC-50 of <100 nM
Figure 7: Methionine restriction significantly reduces mammosphere formation in MCF7 cells
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