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BayFish: Bayesian inference of transcription dynamics from population snapshots of single molecule RNA FISH in single cells

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Figure

Fig. 1 Single-molecule fluorescence in situ hybridization data of Npas4 mRNA in primary neurons after membrane depolarization
Fig. 2 A two-state model of gene expression.parametersratemRNA synthesis (orange arrow), which increasesprobability per unit time (another state: (1) promoter activation (blue arrow), which increases a Each diploid cell has two genetic loci and the promote
Fig. 3 Validating BayFish on synthetic smFISH data. a Example of a technical replicate of synthetic smFISH data generated for an underlyingk1-stimulus model, where n = 100 cells per time point were sampled from the mRNA and active transcription site distri
Fig. 5 Comparing different stimulus models fordifferent initial conditions. The Bayesian posterior distributions for each parameter-stimulus model are shown in Additional file 1: Figure S1
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