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Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid’s anti-metastatic effect in 4T1 tumor bearing mice

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Figure

Table 1: The IC50 of UA on human cancer cell lines (μM, from MTT assay, 48 h treatment)
Table 2: Antiproliferation effects of UA on human breast cancer cell lines (IC50 (μM) from MTT assay, 48 h treatment)
Figure 2: UA inhibits tumor growth and metastasis in vivo. (A) Hemotoxylin & Eosin staining of 4T1 primary tumors (×200 magnification)
Figure 3: UA suppressed tumor lung metastasis, angiogenesis, leukemoid reaction and extensive extramedullary hematopoiesis of the 4T1 tumor-bearing mice
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