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Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor

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Academic year: 2020

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Figure

Fig. 1. Generation of pharmacophore queries used for virtual screening. The highestof the principal subunit and TM2 helix of the complimentary subunit are shown for theopen (cyan) and closed (pink) conformations
Fig. 2. Allosteric modulators of thecompounds from the DrugBank database that were identi a7 nAChR
Fig. 3. Functional characterisation of furosemide on thevarying concentrations of furosemide
Fig. 5. Insingle point mutations S222M, L247A, S248A, M260L and T288A. Data are means of at least three independent experiments
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