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Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development

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Figure

Fig. 1. Loss of Fat1 leads to cranial neural tube defects. (A) Schematic of mouse cortex development
Fig. 2. Fat1intermediate neuronal progenitor markerTbr2 (red, bottom) and with Hoechst (blue).Note that the third ventricle (yellow dottedline) is open incalculated per unit ventricle length, usingimages similar to D
Fig. 3. Fat1 knockdown promotes radial glial precursor proliferation. (A) Schematic of the(K) Fluorescence confocal micrographs of VZ/SVZ/IZ from coronal E16.5 cortical sections stained for Tbr2 (red) and EGFP (green); bottom panels showmerge
Fig. S5A,B) and an increase in Pax6-positive radial precursors
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