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Temporal integration of light flashes by the human circadian system

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Figure

Figure 1. CONSORT flow diagram showing enrollment, allocation, and analysis. Seventy-seven participants were assessed for eligibility
Figure 2. In-lab protocol design. From day 1 to day 14, participants maintained a regular at-home sleep-wake schedule
Figure 3. Change in melatonin phase shift as a function of the ISI. An initial linear rise to peak circadian phase change (~1.85 hours phase delay) was observed when flashes were separated by 2.5 to 7.6 seconds of darkness
Figure 4. Effect of flashes and continuous light on melatonin suppression, objective alertness, and subjective sleepiness
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