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Mechanisms of post-transcriptional regulation of genes involved in FTDP-17

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Figure

Figure 1. Network of possible interactions between proteins and RNAs, at the basis of Fronto Temporal Dementia
Figure 2. Schematic representation of progranulin structure. GRN gene encodes for a protein of 593 amino acids composed by intra-linked granulin peptides that can be cleaved by protease such as elastase or protect in the full-length PGRN conformation throu
Figure 4. Scheme of miRNAs biogenesis. The primary transcript (pri-miRNA) is cleaved by Drosha and DGCR8, generating a miRNA precursor (pre-miRNA) that is exported to the cytoplasm through Exportin5 and Ran-GTP61
Figure 5. Representation of the canonical miRNAs and mirtrons biogenesis pathways. A) Canonical miRNAs biogenesis, through Drosha cleavage of pri-miRNA transcripts
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